Kostenüberlegungen zur Ganzkörper-MRT und PET-CT im Rahmen des onkologischen Stagings

Plathow, Christian; Walz, M.; Lichy, Matthias P.; Aschoff, Philip; Pfannenberg, Christina; Bock, Holger; Eschmann, S. M.; Claussen, Claus D.; Schlemmer, Heinz–Peter

doi:10.1007/s00117-007-1547-z

Cited by 53 publications

(16 citation statements)

References 37 publications

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“…Whole-body MR imaging may be an alternative to FDG-PET/CT [43]; it does not require the operator to work with a potentially harmful radiotracer, the safety profile of MR contrast agents is favorable compared with that of iodinated contrast with CT [44], and the costs for a whole-body MR imaging examination (about 575 euros) are approximately two times less than that of a whole-body FDG-PET/CT examination (about 1,123 euros) [45]. In 1998, Eustace et al [46] showed the potential of whole-body MR imaging in primary tumor detection in four patients with CUP, using a short-tau-inversion-recovery sequence.…”

Section: Discussionmentioning

confidence: 99%

Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis

Kwee

Kwee²

2008

Eur Radiol

274

223

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The aim of this study was to systematically review and meta-analyze published data on the diagnostic performance of combined 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the detection of primary tumors in patients with cancer of unknown primary (CUP). A systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Methodological quality of the included studies was assessed. Reported detection rates, sensitivities and specificities were meta-analyzed. Subgroup analyses were performed if results of individual studies were heterogeneous. The 11 included studies, comprising a total sample size of 433 patients with CUP, had moderate methodological quality. Overall primary tumor detection rate, pooled sensitivity and specificity of FDG-PET/CT were 37%, 84% (95% CI 78–88%) and 84% (95% CI 78–89%), respectively. Sensitivity was heterogeneous across studies (P = 0.0001), whereas specificity was homogeneous across studies (P = 0.2114). Completeness of diagnostic workup before FDG-PET/CT, location of metastases of unknown primary, administration of CT contrast agents, type of FDG-PET/CT images evaluated and way of FDG-PET/CT review did not significantly influence diagnostic performance. In conclusion, FDG-PET/CT can be a useful method for unknown primary tumor detection. Future studies are required to prove the assumed advantage of FDG-PET/CT over FDG-PET alone and to further explore causes of heterogeneity.

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Section: Discussionmentioning

confidence: 99%

Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis

Kwee

Kwee²

2008

Eur Radiol

274

223

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“…Referring to the costs, Plathow et al 61,. performing a cost-analysis study, demonstrated that both whole-body imaging techniques allow substantial reduction of health care costs in many tumour types.…”

Section: Resultsmentioning

confidence: 99%

Comparison between whole-body MRI and Fluorine-18-Fluorodeoxyglucose PET or PET/CT in oncology: a systematic review

Ciliberto¹,

Maggi²,

Treglia³

et al. 2013

Radiology and Oncology

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BackgroundThe aim of the article is to systematically review published data about the comparison between positron emission tomography (PET) or PET/computed tomography (PET/CT) using Fluorine-18-Fluorodeoxyglucose (FDG) and whole-body magnetic resonance imaging (WB-MRI) in patients with different tumours.MethodsA comprehensive literature search of studies published in PubMed/MEDLINE, Scopus and Embase databases through April 2012 and regarding the comparison between FDG-PET or PET/CT and WB-MRI in patients with various tumours was carried out.ResultsForty-four articles comprising 2287 patients were retrieved in full-text version, included and discussed in this systematic review. Several articles evaluated mixed tumours with both diagnostic methods. Concerning the specific tumour types, more evidence exists for lymphomas, bone tumours, head and neck tumours and lung tumours, whereas there is less evidence for other tumour types.ConclusionsOverall, based on the literature findings, WB-MRI seems to be a valid alternative method compared to PET/CT in oncology. Further larger prospective studies and in particular cost-effectiveness analysis comparing these two whole-body imaging techniques are needed to better assess the role of WB-MRI compared to FDG-PET or PET/CT in specific tumour types.

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“…Dies ist verständlich, da bislang weder Qualitätsan-forderungen noch klare Indikationen definiert wurden. Überlegungen zur Kosteneffizienz sind zudem schwer anzustellen [32]. Bei privater Krankenversicherung kann daher bislang nur der allgemeine Höchstwert für eine MRT angesetzt werden.…”

Section: Kostenüberlegungenunclassified

Onkologische Diagnostik mittels Ganzkörper-MRT

Schlemmer

2009

best practice onkologie

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Was ist möglich, wo liegen die Grenzen?Die Ganzkörper-MRT ist ein hochempfindliches Verfahren zum lokalen Staging verschiedener Tumorentitäten sowie zur Detektion von Fernmetastasen. Ihr Einsatz führt zu einem effizienteren Patientenmanagement mit verbesserter und beschleunigter Diagnostik, verkürzter Zeit zwischen Diagnostik und Therapie sowie zu einem verbesserten Therapiemonitoring. Der Beitrag gibt einen Überblick über die derzeit verfügbaren schnittbildgebenden Verfahren und gibt den aktuellen Stand zum Einsatzes der Ganzkörper-MRT wieder. 46 CME · TOPIC · ganzkörper-mr t Seite 52Buchtipps: Literatur zur Magnetresonanzbildgebung Seite 50Aktuell: Derzeit verfügbare MRTGanzkörpersysteme in der Übersicht best practice onkologie | 2 · 2009 4: 46-55 |

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Kostenüberlegungen zur Ganzkörper-MRT und PET-CT im Rahmen des onkologischen Stagings

Cited by 53 publications

References 37 publications

Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis

Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis

Comparison between whole-body MRI and Fluorine-18-Fluorodeoxyglucose PET or PET/CT in oncology: a systematic review

Onkologische Diagnostik mittels Ganzkörper-MRT

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