Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway

Mitra, Ankita; Rahmawati, Laily; Lee, Hwa Pyoung; Kim, Seung A; Han, Chang-Kyun; Hyun, Sun Hee; Cho, Jae Youl

doi:10.1016/j.jgr.2022.04.003

Cited by 13 publications

(10 citation statements)

References 45 publications

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“…As stated in the Introduction, Cd as a pollutant is closely associated with the occurrence of lung cancer and its related diseases (Cao et al, 2021;Lener et al, 2021). Am et al (2022) (Nka & Qar, 2021). Vanillin was found able to relieve CdCl 2caused lung damage by attenuating inflammation and lung barrier dysfunction (Liu et al, 2021).…”

Section: Discussionmentioning

confidence: 96%

“…Am et al. (2022) reported that CdSO 4 could cause lung damage while inducing lung histopathological changes in mice and inflammation in A549 cells. Similar result was revealed in the present research: Cd exposure caused lung injury, which reduced mice body weight, increased lung W/D ratio, caused lung histological changes, and induced oxidative stress, apoptosis, and inflammation.…”

Section: Discussionmentioning

confidence: 99%

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The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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Cadmium (Cd) is a heavy metal toxic that can cause health problems including lung injury. This study was set out to meet the growing demand for effective treatment of lung diseases and explore the mechanism of caffeic acid phenethyl ester (CAPE, a natural phenolic acid) protect against Cd‐caused lung damage. In this study, CAPE significantly increased mice body weight, decreased lung W/D ratio, and alleviated histomorphological injury. CAPE mitigated CdCl2‐induced oxidative stress through Nrf2/HO‐1/NQO1 pathway, suppressed inflammation via MyD88/NF‐κB pathway, and alleviated apoptosis by modulating apoptosis mediators. CAPE also inhibited the CdCl2‐caused decreasing of TLR4 level and the increasing of miR‐182‐5p level, which is achieved by miR‐182‐5p sponging TLR4. Collectively, miR‐182‐5p is involved in CAPE against CdCl2‐caused lung damage by targeting TLR4. MiR‐182‐5p/TLR4 is a new pathway for inhibiting oxidative stress, apoptosis, and inflammation in CAPE‐mediated lung protection, which provides a novel avenue for treatment therapies.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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“…After recording the wet weight, the lung tissue was dried using an oven at 60 • C for 72 h, and the weight of the dried lung tissue was measured. Wet-to-dry ratios were calculated to assess the degree of inflammation in the lung tissue [35,36]. The protein concentration ratio was analyzed using the collected BALF.…”

Section: Lung Wet-to-dry Weight Ratio and Protein Concentration Ratio...mentioning

confidence: 99%

“…The fixed samples were embedded with paraffin, cut to a thickness of 3 µm, and then stained with Hematoxylin & Eosin. Lung injury was assessed by analyzing septal thickening of the alveolar walls, neutrophil infiltration, and membrane structure formation composed of cell debris according to a previously published paper [36,37] and as described in Table 1. Then, 500 µL BALF was extracted from the trachea of each mouse with 100 µM EDTA in 1 mL PBS.…”

Section: Histological Analysis Of Lung Tissuementioning

confidence: 99%

“…It was prepared at the same concentration for each group (n = 5/group) by adjusting with PBS based on Bradford assay. To obtain the lung tissue lysates, lung tissue was lysed by treating cell lysis buffer and homogenized with sonicator [36]. Tissue lysates were centrifuged at 11,000× g for 5 min at 4 • C, and supernatants were used for ELISA.…”

Section: Histological Analysis Of Lung Tissuementioning

confidence: 99%

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Chloroform Fraction of Prasiola japonica Ethanolic Extract Alleviates UPM 1648a-Induced Lung Injury by Suppressing NF-κB Signaling

Park

Kim

Song

et al. 2022

Foods

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Prasiola japonica is an edible alga, and the ethanol extract of P. japonica (Pj-EE) possesses various biological activities. Interestingly, in a recent study, we observed the potent anti-inflammatory activity of the chloroform fraction of Pj-EE (Pj-EE-CF). Thus, to extend the application of Pj-EE-CF, we further studied its effects on lung injury. To establish an experimental model of lung injury, we nasally administered urban particulate matter UPM 1648a (50 mg/kg) to mice. In addition, BEAS-2B cells were treated with 300 μg/mL of UPM 1648a for in vitro analysis. Intranasal administration of UPM 1648a increased lung injury score, macrophage infiltration, and upregulation of the inflammatory enzyme inducible nitric oxide synthase (iNOS) in lung tissues. On the other hand, oral administration of Pj-EE-CF (25, 50, and 100 mg/kg) alleviated these pathological features as assessed by lung wet/dry ratio, lung injury score, bronchoalveolar lavage fluid (BALF) protein amount in the lung tissues up to 70%, 95%, and 99%, respectively. In addition, Pj-EE-CF down-regulated the release of inflammatory cytokines, interleukins (ILs), tumor necrosis factor (TNF)-α, and interferon (IFN)-γ elevated by UPM 1648a in the lung tissues and lung BALF up to 95%. According to Western blot and luciferase assay, Pj-EE-CF (100 mg/kg in vivo or 50 and 100 μg/mL in vitro) significantly reduced the nuclear factor-κB (NF-κB) signal activated by UPM 1648a. Finally, UPM 1648a increased cellular reactive oxygen species (ROS) levels in BEAS-2B cells, while Pj-EE-CF reduced them. These results suggest that Pj-EE-CF alleviates UPM 1648a-induced lung damage via anti-inflammatory and antioxidant activities and by suppressing NF-κB signaling. In conclusion, these observations imply that Pj-EE-CF could be a practical component of food supplements to mitigate air pollution-derived lung damage.

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The properties and mechanism of action of plant immunomodulators in regulation of immune response – A narrative review focusing on Curcuma longa L., Panax ginseng C. A. Meyer and Moringa oleifera Lam

Balasubramaniam,

Sapuan,

Hashim

et al. 2024

Heliyon

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Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway

Cited by 13 publications

References 45 publications

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Chloroform Fraction of Prasiola japonica Ethanolic Extract Alleviates UPM 1648a-Induced Lung Injury by Suppressing NF-κB Signaling

The properties and mechanism of action of plant immunomodulators in regulation of immune response – A narrative review focusing on Curcuma longa L., Panax ginseng C. A. Meyer and Moringa oleifera Lam

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