Korean red ginseng stimulates insulin release from isolated rat pancreatic islets

The Effect of Metformin and Ginseng on Alloxan-Induced Diabetic Rats: Hematological, Biochemical and Histopathological Studies

“…Treatment with metformin resulted in a remarkable preservation of pancretic β-cells from further damage by oxidative stress as a result of its hypoglycemic effect in agreement with Salman et al (2013). Also, ginseng-treated group showed moderate ameliorative effect on hyperglycemic β-cells damage and the possible explanation may be that ginseng has been shown to exhibit an anti-apoptotic function on pancreatic β-cells via regulation of nitric oxide and reactive oxygen species production (ROS scavenging) (Kim and Kim, 2008). The cause of hepatic lesionsof diabetic untreated rats may be depletion of enzymatic and non-enzymatic anti-oxidants of liver tissues due to over production of ROSresulting in excessive lipid peroxidation as well as fragmentation of mitochondria, Geolgi apparatus and rough endoplasmic reticulum leading to hepatocytes destruction (Abdultawab and Ayuob, 2013).…”

An overview on antidiabetic medicinal plants having insulin mimetic property

“…The aqueous ethanolic extract of Korean red ginseng significantly evoked a insulin release in a glucose-independent manner [39] .…”

A Review on Anti-diabetic Plants

“…17 Panax notoginseng: P. notoginseng roots was evaluated as a candidate to improve hyperglycemia by in vitro muscle cells screening test. 18 Arecaceae Phoenix dactylifera L.: The effectiveness of hydroalcoholic extract of P. dactylifera leaves was evaluated in animal models of type II diabetes.…”

“…Rheum undulatum: A stilbene, desoxyrhapontigenin (16) and two anthraquinones, emodin (17) and chrysophanol (18) were isolated from cultivated Korean rhubarb rhizomes (R. undulatum), which were found to reduce postprandial hyperglycemia. 73 …”