Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety

Vuksan, Vladimir; Sung, Mi‐Kyung; Sievenpiper, John L.; Stavro, P. Mark; Jenkins, Alexandra L.; Buono, Marco Di; Lee, Kwang-Seung; Leiter, Lawrence A.; Nam, Ki Yeul; Arnason, John T.; Choi, Melody; Naeem, Asima

doi:10.1016/j.numecd.2006.04.003

Cited by 244 publications

(189 citation statements)

References 30 publications

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“…Previous studies have shown that ginseng was able to reduce blood glucose level in type 2 diabetes patients (Vuksan et al 2008), normal people (Reay et al 2006), and diabetic mice (Attele et al 2002, Xie et al 2005c. Because glucose uptake in target tissues is a critical step in maintaining glucose homeostasis and in clearing the postprandial glucose load (Herman & Kahn 2006), our results may explain partially the mechanism of ginseng's hypoglycemic effects.…”

Section: Discussionsupporting

confidence: 50%

Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes

Shang

Yang²,

Zhou³

et al. 2008

Journal of Endocrinology

102

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A series of clinical trials and animal experiments have demonstrated that ginseng and its major active constituent, ginsenosides, possess glucose-lowering action. In our previous study, ginsenoside Rb 1 has been shown to regulate peroxisome proliferator-activated receptor g activity to facilitate adipogenesis of 3T3-L1 cells. However, the effect of Rb 1 on glucose transport in insulin-sensitive cells and its molecular mechanism need further elucidation. In this study, Rb 1 significantly stimulated basal and insulin-mediated glucose uptake in a time-and dose-dependent manner in 3T3-L1 adipocytes and C2C12 myotubes; the maximal effect was achieved at a concentration of 1 mM and a time of 3 h. In adipocytes, Rb 1 promoted GLUT1 and GLUT4 translocations to the cell surface, which was examined by analyzing their distribution in subcellular membrane fractions, and enhanced translocation of GLUT4 was confirmed using the transfection of GLUT4-green fluorescence protein in Chinese Hamster Ovary cells. Meanwhile, Rb 1 increased the phosphorylation of insulin receptor substrate-1 and protein kinase B (PKB), and stimulated phosphatidylinositol 3-kinase (PI3K) activity in the absence of the activation of the insulin receptor. Rb 1 -induced glucose uptake as well as GLUT1 and GLUT4 translocations was inhibited by the PI3K inhibitor. These results suggest that ginsenoside Rb 1 stimulates glucose transport in insulin-sensitive cells by promoting translocations of GLUT1 and GLUT4 by partially activating the insulin signaling pathway. These findings are useful in understanding the hypoglycemic and anti-diabetic properties of ginseng and ginsenosides.

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Section: Discussionsupporting

confidence: 50%

Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes

Shang

Yang²,

Zhou³

et al. 2008

Journal of Endocrinology

102

View full text Add to dashboard Cite

show abstract

“…Compared with placebo, intervention with Panax ginseng extract capsules and OHA, significantly improved glucose tolerance and insulin sensitivity in a double-blind, placebocontrolled crossover randomised clinical trial (V. Vuksan et al, 2008). There were no significant changes in HbA1c as well as safety biochemical parameters of liver and kidneys.…”

Section: Single Botanical Preparations With Oral Hypoglycaemic Agentmentioning

confidence: 99%

“…Schulz et al, 1995). One trial was a crossover randomised trial (V. Vuksan et al, 2008), while the rest was parallel-group design. Recruitment of patients was limited to the centres of the studies.…”

Section: Risks Of Biasmentioning

confidence: 99%

“…Vuksan et al, 2008). Among them, three used simple randomisation methods (random number generator, table and computer generated sequence) (A.M. Dans et al, 2007; T. Mackenzie et al, 2007;V. Vuksan et al, 2008), one used block randomisation technique (P. Crawford, 2009) and another used a balanced randomisation technique (H.F. Huseini et al, 2006).…”

Section: Risks Of Biasmentioning

confidence: 99%

“…Crawford, 2009;A.M. Dans et al, 2007; T. Mackenzie et al, 2007; V. Vuksan et al, 2008). Potential confounding factors were not elaborated in four papers (S.M.…”

Section: Risks Of Biasmentioning

confidence: 99%

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