Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

Kim, Jin Won; Han, Sae Won; Cho, Jae Yong; Chung, Ik Joo; Kim, Jong Gwang; Lee, Kyung Hee; Park, Keon Uk; Baek, Sun Kyung; Oh, Sang Cheul; Lee, Myung Ah; Oh, Doyeun; Shim, Bong Suk; Ahn, Joong Bae; Shin, Donghyun; Lee, Jae Won; Kim, Yeul Hong

doi:10.1016/j.ejca.2020.02.018

Cited by 42 publications

(62 citation statements)

References 35 publications

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“…Particularly, chemotherapy and radiotherapy were major factors that can develop severe fatigue [ 118 , 119 ]. Red ginseng can moderate chemotherapy-induced fatigue in colorectal cancer patients, especially older and female patients [ 105 ]. Red ginseng can significantly reduce BFI scores over 8 weeks and 16 weeks.…”

Section: Anti-fatigue Effect In the Clinical Settingmentioning

confidence: 99%

“…Reviewing all the studies targeted on diseases-related fatigue, P. ginseng was an effective supplementation in clinical treating diseases-related fatigue. For example, red ginseng can significantly improve mood, relations with others, walking ability and enjoyment of life in colorectal cancer patients with chemotherapy [ 105 ]. Oral ginseng also can improve quality of life, such as muscular pain, degree of happiness, appetite and sleep quality, as well as mood condition in nonmetastatic cancer patients [ 104 ].…”

Section: Anti-fatigue Effect In the Clinical Settingmentioning

confidence: 99%

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Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review

Liu

Wang

2021

Foods

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As an ancient Chinese herbal medicine, Panax ginseng C.A. Meyer (P. ginseng) has been used both as food and medicine for nutrient supplements and treatment of human diseases in China for years. Fatigue, as a complex and multi-cause symptom, harms life from all sides. Millions worldwide suffer from fatigue, mainly caused by physical labor, mental stress, and chronic diseases. Multiple medicines, especially P. ginseng, were used for many patients or sub-healthy people who suffer from fatigue as a treatment or healthcare product. This review covers the extract and major components of P. ginseng with the function of anti-fatigue and summarizes the anti-fatigue effect of P. ginseng for different types of fatigue in animal models and clinical studies. In addition, the anti-fatigue mechanism of P. ginseng associated with enhancing energy metabolism, antioxidant and anti-inflammatory activity is discussed.

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Section: Anti-fatigue Effect In the Clinical Settingmentioning

confidence: 99%

Section: Anti-fatigue Effect In the Clinical Settingmentioning

confidence: 99%

Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review

Liu

Wang

2021

Foods

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“…Although the cause of CRF is obvious, there is currently no effective management or prevention strategy available [2]. Nonpharmaceutical treatments have poor compliance and long-term treatment cycles, while drug-based treatments often cause insomnia, palpitations, anxiety, anorexia, and metabolic abnormalities, as well as a series of adverse side effects that can seriously affect the patient's quality of life [4,6,7]. Thus, novel and safe management strategies for CRF are urgently required.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology/Metabolomics‐Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer‐Related Fatigue

Guo

Liu

Zheng

et al. 2021

Oxidative Medicine and Cellular Longevity

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Chinese herbal medicines have multiple targets and properties, and their use in multidisciplinary cancer therapies has consequently received increasing attention. Here, we have investigated the possible active ingredients associated with cancer-related fatigue (CRF) in the Shengqi Fuzheng Injection (SFI). In vitro cell models were used to measure the regulation effects of SFI on CRF. Metabolomic analysis was used to identify the potential genes and pathways in C2C12 mouse myoblasts treated with SFI, and the interaction of compounds and CRF targets was predicted using network pharmacology and molecular docking analyses. The putative pathways were further verified using immuno-blotting assays. The results showed that SFI significantly inhibited muscle cell apoptosis and increased the mitochondrial membrane potential of muscle cells. The network pharmacology analysis results identified 36 candidate compounds, and 244 potential targets were yielded by SFI, and they shared 10 key targets associated with cancer-related fatigue. According to the enrichment analysis and experimental validation, SFI might ameliorate muscle cell mitochondrial function by activating AMPK and inhibiting the PI3K/Akt signaling pathways, and the expression changes of mitochondrial metabolic enzymes MnSOD and apoptosis-associated proteins Bax and Bcl-2 were also triggered. The functions and mechanisms of SFI in anticancer-related fatigue were found here to be at least partly due to the targeting of the AMPK and PI3K/Akt signaling pathways, and this has highlighted new potential applications for network pharmacology when researching Chinese Medicines.

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“…Numerous studies on the pharmacological efficacy of KRG have been published through in vitro, in vivo, and clinical trials. In a study by Kim et al [ 5 ], patients with colorectal cancer who received mFOLFOX-6 chemotherapy were randomly administered either KRG 2000 mg/day or placebo for 16 weeks. Compared to the placebo group, the KRG group had reduced cancer-related fatigue [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a study by Kim et al [ 5 ], patients with colorectal cancer who received mFOLFOX-6 chemotherapy were randomly administered either KRG 2000 mg/day or placebo for 16 weeks. Compared to the placebo group, the KRG group had reduced cancer-related fatigue [ 5 ]. Moreover, 12-week KRG administration to menopausal women significantly increased superoxide dismutase (SOD) activity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Immune Activity of Polysaccharide Fractions Isolated from Korean Red Ginseng

et al. 2020

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Korean red ginseng (KRG)’s pharmacological efficacy and popular immunomodulatory effects have already been proven in many studies; however, the component of KRG that is effective in immune activity has not been studied before. Therefore, this study extracted and separated KRG for an immune activity comparison. In the water fraction obtained by extracting KRG powder with water, a red ginseng neutral polysaccharide (RGNP) fraction and a red ginseng acidic polysaccharide (RGAP) fraction were obtained. Each fraction was orally administered for 10 days to mice with reduced immunity, and the number of IgM antibody-forming cells (AFCs) in splenocytes was measured to compare the immune activity of the water fractions. The results showed that the RGAP fraction has the greatest number of AFCs. To set the optimal dose of the RGAP fraction, which had the highest immune activity, the AFCs, macrophage activity, and splenocyte subtype in the mice were analyzed. As a result, the number of AFCs was significantly increased in the RGAP fraction compared to RGNP. The intraperitoneal macrophage phagocytosis activity and the number of T cells, B cells, and macrophages in the spleen increased significantly. It can, therefore, be confirmed that immune activity increases by a fraction containing higher RGAP content, and we hypothesize that RGAP activates immune activity.

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Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

Abstract: Meeting presentation: The results of this study were presented at the ASCO 2017 annual meeting in Chicago, USA.

Cited by 42 publications

References 35 publications

Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review

Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review

Network Pharmacology/Metabolomics‐Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer‐Related Fatigue

Immune Activity of Polysaccharide Fractions Isolated from Korean Red Ginseng

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