Korean Red Ginseng enhances cardiac hemodynamics on doxorubicin-induced toxicity in rats

Jang, Youngjin; Lee, Dongbin; Hossain, Mohammad Amjad; Aravinthan, Adithan; Kang, Chang-Won; Kim, Nam Soo; Kim, Jong-Hoon

doi:10.1016/j.jgr.2019.03.002

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…Meanwhile, this group revealed a significant increase in SOD activity associated with a significant decrease in MDA level compared with doxorubicin group. These results in accordance, partially, with those reported by Young et al (2019) who reported that ginseng enhance the activity of the antioxidant enzymes (SOD, CAT, GSH and GSH-Px) on doxorubicin-induced toxicity in rats. The improving effect of ginseng may be explained by what was reported by Kitts et al (2000) that ginseng extract have the ability to scavenge superoxide radicals and inhibit lipid peroxidation through transition metal chelation.…”

Section: Discussionsupporting

confidence: 93%

Protective role of ginseng extract against oxidative stress, reproductive and some biochemical parameters alterations induced by doxorubicin in male rats

Kassem

Ali

Abo-Kora

et al. 2020

IJPT

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This study investigates the modulating effect of ginseng against testicular toxicity, oxidative stress and changes in some biochemical parameters induced by doxorubicin. Twenty male rats were divided into four groups. The 1st group received distilled water orally (control group), The 2nd group received doxorubicin (5 mg/kg b.wt. intrapertenoineal) once a week for eight weeks, The 3rd group received ginseng extract (200 mg/kg b.wt.) daily for eight weeks and the 4th group received doxorubicin with ginseng extract by the same doses as in the 2nd and the 3rd groups respectively. At the end of the 8th week, blood and semen samples were taken for biochemical and semen analysis, respectively. The doxorubicin treated group had significantly higher serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), Creatine kinase (CK) and lactate dehydrogenase (LDH) along with lower levels of total protein, albumin and globulin. In addition, a significant decrease in antioxidant enzymes (SOD, CAT, GSHPx), and glutathione (GSH) associated with higher level of malondialdehyde (MDA) were observed. At the same time, the group that took doxorubicin with ginseng did not differ from control group in terms of these parameters. Male fertility study showed changes in testosterone and semen analysis in both groups treated with doxorubicin, while the group that took doxorubicin with ginseng showed an improvement towards control levels of these parameters. Thus ginseng supplement can reduce the negative effects of doxorubicin- induce.

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Section: Discussionsupporting

confidence: 93%

Protective role of ginseng extract against oxidative stress, reproductive and some biochemical parameters alterations induced by doxorubicin in male rats

Kassem

Ali

Abo-Kora

et al. 2020

IJPT

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“…First, Panax ginseng reduces cardiac troponin and brain natriuretic peptide during doxorubicin-induced cardiotoxicity and has a protective effect. This modulation of cardiac troponin reinforces the research of Jang et al [12], [19].…”

Section: Discussionsupporting

confidence: 89%

“…Some research proposed management of Hb concentration, Mean corpuscular volume (MCV), MCV, Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Packed cell volume(PCV), and other blood markers to assess medication toxicity [15]. Other research suggests using histological change after medication toxicity [12], [18].…”

Section: Sample Collectionmentioning

confidence: 99%

“…Panax is a medicinal plant found all over the world that belongs to the Panax family. Panax ginseng is known for its unique components, as it contains more than 40 active substances and ingredients such as ginsenosides, polyacetylenes, polysaccharides, and peptidoglycans [10], [12]. This ginseng plant has recently received much attention for its use in the diagnosis and treatment of many diseases including kidney failure prevention, hepatoprotections, reduction of neurotoxicity and may also reduce cardiotoxicity due to oxidative stress [13], [14], for that reason several studies have been asked about its potency to treat this disorder but till now few studies success by powerful biomarkers and histological methods.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways

Al-Hussaniy¹,

Al-Kuraishy²,

Abdulameer

2022

Open Access Maced J Med Sci

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BACKGROUND: Doxorubicin (DOX) is a broad-spectrum anti-cancer drug that is used to treat a variety of cancers, including blood cancers such as leukemia and solid tissue cancers. However, its use some time limited because of its cardiotoxicity. OBJECTIVE: The objective of the study was to determine the cardioprotective effect of ginseng in the case of cardiotoxicity caused by doxorubicin therapy. Methods: Thirty experimental animals (male Sprague Wistar rats) were used in this research and they were separated into three groups: Rats in Group I (n# = 10) were given distilled water plus normal saline, rats in Group II (n# = 10) were given distilled water plus doxorubicin, and rats in Group III (n# = 10) were given Panax ginseng plus doxorubicin. Serum concentration, malondialdehyde (MDA), glutathione reductase (GSH), lipid peroxidase (LPO), TNF (ng/L), cardiac troponin (ng/L), brain natriuretic peptide BNP(g/L), and caspase-3 (pmol/L) levels were measured in all groups. RESULTS: Doxorubicin caused substantial cardiotoxicity as a result of a significant increase in the elevation of cTnI to 40.09 ± 6.67 (ng/L). In addition, MDA, LPO, TNF-α, and caspase-3 levels were increased in doxorubicin group compared to the control group p < 0.05. Panax ginseng reduced cardiac troponin (cTnI) However, its effect on reduction of BNP levels insignificantly compared to the doxorubicin group p = 0.06. Panax ginseng reduced LPO and MDA and raised the antioxidant potential biomarker GSH significantly compared to the doxorubicin group p < 0.05. Panax ginseng significantly reduced inflammatory (TNF-α) and apoptotic (caspase-3) biomarkers when compared to the doxorubicin group. CONCLUSIONS: According to the findings of this study, Panax ginseng suppresses reactive oxygen species and inflammatory and apoptotic pathways in experimental rats, thereby preventing doxorubicin-induced cardiovascular events.

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“…In accordance with our findings, it has been shown that DOX intoxication resulted in the elevation of cardiac MPO activity in DOX‐treated rats. [ 81,82 ] Our data revealed that treatment with TRE alone or in combination with DOX significantly reduced the myocardial MPO activities as compared to the DOX‐treated group. Hence, it is plausible that TRE decreased MPO‐induced ROS generation and, accordingly, reduced the myocardial damage in DOX‐treated mice.…”

Section: Discussionmentioning

confidence: 77%

Trehalose alleviates doxorubicin‐induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy

Abu-Khudir

Ibrahim

Shams

et al. 2021

J Biochem & Molecular Tox

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Clinically, the use of doxorubicin (DOX) is limited due to DOX-induced cardiotoxicity (DIC). The current study aimed to evaluate the cardioprotective effect of trehalose (TRE) against DIC in a female Swiss albino mouse model. Mice were divided into five experimental groups: Gp. I: saline control group (200 μl/mouse saline three times per week for 3 weeks day after day), Gp. II: DOX-treated group (2 mg/kg body weight three times per week for 3 weeks day after day), Gp. III: TRE group (200 μg/mouse three times per week for 3 weeks day after day), Gp. IV: DOX + TRE cotreatment group (animals were coadministered with DOX and TRE as in Gp. II and III, respectively), and Gp. V: DOX + TRE posttreatment group (animals were treated with DOX as in Gp. II followed by treatment with TRE as in Gp. III). DOX-treated mice showed significant elevation in cardiac injury biomarkers (lactate dehydrogenase, creatine kinase isoenzyme-MB, and cardiac troponin I), cardiac oxidative stress (OS) markers (malondialdehyde and myeloperoxidase), and cardiac levels of autophagyrelated protein 5. Moreover, DOX significantly reduced the levels of total antioxidant capacity and activities of catalase and glutathione S-transferase.In contrast, TRE treatment of DOX-administered mice significantly improved almost all of the above-mentioned assessed parameters. Furthermore, histopathological changes of cardiac tissues observed in mice treated with TRE in combination with DOX were significantly improved as compared to DOXtreated animals. Taken together, the present study provides evidence that TRE has cardioprotective effects against DIC, which is likely mediated via suppression of OS and autophagy.

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Korean Red Ginseng enhances cardiac hemodynamics on doxorubicin-induced toxicity in rats

Cited by 5 publications

References 35 publications

Protective role of ginseng extract against oxidative stress, reproductive and some biochemical parameters alterations induced by doxorubicin in male rats

Protective role of ginseng extract against oxidative stress, reproductive and some biochemical parameters alterations induced by doxorubicin in male rats

The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways

Trehalose alleviates doxorubicin‐induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy

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