Korean Experiences of the Treatment of Esophageal Squamous Cell Carcinoma

Kim, Dae Joon; Park, Sung Yong; Hong, Min Hee

doi:10.1007/978-981-15-4190-2_19

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…[31] Yasuda et al reported abnormal accumulation of the p53 protein at precancerous stages, such as basal cell hyperplasia or dysplasia of the esophagus, suggesting that p53 mutations are essential even in the early stage of esophageal squamous cell carcinogenesis. [33,34] Abnormal P63 expression is upregulated in squamous neoplastic conditions and may contribute to squamous carcinogenesis. [35] Additionally, P16 [36] is a tumor suppressor gene product, while C-myc [37] is a cancer gene protein.…”

Section: Biomarkers Of Esophageal Precancerous Lesionsmentioning

confidence: 99%

Recent advances in esophageal squamous cell precancerous conditions: A review

2022

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Esophageal squamous cell carcinoma (ESCC) is a common cancer in many developing countries in Asia and Africa, with a 5-year survival rate of approximately 20%. Most cases are diagnosed at an advanced age when there is no effective treatment strategy. Esophageal precancerous conditions have a much better prognosis, with a 5-year survival rate of over 90% by endoscopic diagnosis and treatment. Nevertheless, limitations, contraindications, and lymph node metastasis incompetency of endoscopy. Thus, the diagnosis and treatment of esophageal precancerous lesions remain a significant challenge. Biomarker investigations provide opportunities for target detection and therapy. Additionally, drug development is ongoing. Changes in lifestyle habits, such as diet balance, smoking and alcohol cessation, are beneficial for the prognosis of esophageal precancerous lesions. Collectively, multiple and sequential diagnoses and treatments are essential for curing esophageal precancerous lesions and reducing the incidence and mortality of ESCC.Abbreviations: CIS = carcinoma in situ, Egr-1 = early growth response gene-1, ESCC = esophageal squamous cell cancer, FHIT = fragile histidine triad, HE = Hematoxylin-Eosin, HGF = hepatocyte growth factor, HGIN = high-grade intraepithelial neoplasia, IMP1 = insulin-like growth factor II mRNA-binding protein 1, LGIN = low-grade intraepithelial neoplasia, MTHFR = 677T methylenetetrahydrofolate reductase, PAX9 = paired box 9, PHCA = plant-associated human cancer antigen, SCCAs = squamous cell carcinoma antigens, USP9X = ubiquitin-specific peptidase 9, USPs = ubiquitin-specific peptidases.

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Section: Biomarkers Of Esophageal Precancerous Lesionsmentioning

confidence: 99%

Recent advances in esophageal squamous cell precancerous conditions: A review

2022

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“…The currently used da Vinci Surgical System provides key functions such as 3-dimensional vision, tremor filtering, motion scaling, and the endo-wrist function, which are expected to decrease the incidence of morbidity after RAMIE compared to that after VATS-E [ 1 - 4 ]. Since the first RAMIE in Korea, performed by our team (Severance Hospital) in July 2006, we have developed useful techniques for radical esophagectomy with favorable postoperative and oncologic outcomes [ 5 - 9 ]. Although novel devices and technologies have been introduced in the past decade, understanding the microanatomy of the esophagus and related structures is a prerequisite for the success of RAMIE.…”

Section: Introductionmentioning

confidence: 99%

Robot-Assisted Thoracoscopic Esophagectomy with Total Mediastinal Lymphadenectomy: A Guide to a Systematic Approach Using the Concept of Fascial Plane Dissection

Park

Kim

2021

J Chest Surg

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Recent case series and meta-analyses have suggested that robot-assisted minimally invasive esophagectomy (RAMIE) could be a useful alternative to video-assisted thoracic surgery esophagectomy. The advantages of RAMIE are a 3-dimensional view, 7 degrees of freedom, and tremor filtering, which enable more meticulous lymph node dissection with a lower incidence of complications. However, in radical esophagectomy, understanding the concepts of the fascia and compartment is crucial for successful and reliable dissection. The first RAMIE in Korea was performed by our team in July 2006, and since then, we have developed related techniques to achieve better short- and long-term outcomes. The key step in RAMIE for esophageal squamous cell carcinoma is dissection of the upper mediastinum due to the difficulty of lymph node dissection and the high incidence of nodal metastasis in the area. Herein, we describe the technique of fascial plane dissection with esophageal suspension during RAMIE.

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Robot-Assisted Thoracoscopic Esophagectomy with Total Mediastinal Lymphadenectomy: A Guide to a Systematic Approach Using the Concept of Fascial Plane Dissection

Park

Kim

2022

Techniques in Minimally Invasive Thoracic Surgery

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Korean Experiences of the Treatment of Esophageal Squamous Cell Carcinoma

Cited by 3 publications

References 47 publications

Recent advances in esophageal squamous cell precancerous conditions: A review

Recent advances in esophageal squamous cell precancerous conditions: A review

Robot-Assisted Thoracoscopic Esophagectomy with Total Mediastinal Lymphadenectomy: A Guide to a Systematic Approach Using the Concept of Fascial Plane Dissection

Robot-Assisted Thoracoscopic Esophagectomy with Total Mediastinal Lymphadenectomy: A Guide to a Systematic Approach Using the Concept of Fascial Plane Dissection

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