Kontrollierbare Zeitverzögerung beim Aufplatzen von oxidationsempfindlichen, mittels PISA synthetisierten Polymersomen

Sobotta, Fabian H.; Kuchenbrod, Maren T.; Gruschwitz, Franka V.; Festag, Grit; Bellstedt, Peter; Hoeppener, Stephanie; Brendel, Johannes C.

doi:10.1002/ange.202108928

Cited by 3 publications

(9 citation statements)

References 72 publications

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“…PNAM‐ b ‐PNAT vesicles were prepared by PISA, and cargo molecules, such as dyes and enzymes, effectively encapsulated in situ. [ 140 ] The encapsulation of glucose oxidase resulted in glucose‐sensitive vesicles, as small molecules including sugars can passively penetrate their membrane. The produced H 2 O 2 oxidized the PNAT block leading to a disassembly process (Figure 13D).…”

Section: Formation Of Biomolecule‐loaded Polymeric Nanostructures Via...mentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Qiu

Han

Xing

et al. 2023

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The combination of biomolecules and synthetic polymers provides an easy access to utilize advantages from both the synthetic world and nature. This is not only important for the development of novel innovative materials, but also promotes the application of biomolecules in various fields including medicine, catalysis, and water treatment, etc. Due to the rapid progress in synthesis strategies for polymer nanomaterials and deepened understanding of biomolecules’ structures and functions, the construction of advanced polymer‐based biohybrid nanostructures (PBBNs) becomes prospective and attainable. Polymerization‐induced self‐assembly (PISA), as an efficient and versatile technique in obtaining polymeric nano‐objects at high concentrations, has demonstrated to be an attractive alternative to existing self‐assembly procedures. Those advantages induce the focus on the fabrication of PBBNs via the PISA technique. In this review, current preparation strategies are illustrated based on the PISA technique for achieving various PBBNs, including grafting‐from and grafting‐through methods, as well as encapsulation of biomolecules during and subsequent to the PISA process. Finally, advantages and drawbacks are discussed in the fabrication of PBBNs via the PISA technique and obstacles are identified that need to be overcome to enable commercial application.

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Section: Formation Of Biomolecule‐loaded Polymeric Nanostructures Via...mentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Qiu

Han

Xing

et al. 2023

Small

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“…Non‐covalent interactions allow for cargo retention within the particle, that is, the hydrophobic core (Figure 4, top). For hydrophilic cargo, entrapment in the aqueous lumen of polymersomes is also feasible 97–99 . With covalent linkages, the cargo can in principle be incorporated at any desired location on the BCP (Figure 4, middle and bottom).…”

Section: (Therapeutic) Cargo Encapsulation In Pisa‐npsmentioning

confidence: 99%

“…Early examples of PISA studies 127,128 neglected the impact of cargo on the polymerization kinetics and the morphological outcome. However, recent studies refuted cargo inertness 106,108 and revealed significant impact on the PISA process as a function of the physical–chemical properties of the cargo 106,107 and its concentration in the reaction mixture 97,98 . In a pioneering example, Cao et al systematically studied the influence of drug loading on the morphology of PISA‐NPs 106 .…”

Section: (Therapeutic) Cargo Encapsulation In Pisa‐npsmentioning

confidence: 99%

“…The cargo may not just impact the SA process, but also the polymerization kinetics. Cargo‐mediated radical chain transfer and/or scavenging may limit control over the polymerization kinetics and resulting polymer architecture, especially at high cargo concentrations 98 . For photo‐initiated polymerizations, additional interferences may occur due to optical properties of the cargo, for example, if the cargo's absorption spectrum overlaps with the wavelength of the initiating light source.…”

Section: (Therapeutic) Cargo Encapsulation In Pisa‐npsmentioning

confidence: 99%

“…Inspiration for these designs was drawn from BCP‐based DDS prepared via conventional SA methods 91 . In the development of such systems, a dye is typically encapsulated in situ to demonstrate and study the triggered release 97,98,109–111,114 . Often, the mechanism is based on a hydrophobic‐to‐hydrophilic transition of the core‐forming block to disassemble the micelles and release the cargo (Figure 7, Strategy i ).…”

Section: (Therapeutic) Cargo Encapsulation In Pisa‐npsmentioning

confidence: 99%

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Polymerization‐induced self‐assembly for drug delivery: A critical appraisal

Hochreiner,

van Ravensteijn

2023

Journal of Polymer Science

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Polymerization‐induced self‐assembly (PISA) with (in situ) encapsulation of (therapeutic) cargo has proven to be an efficient preparation method for loaded polymeric micelles and polymersomes, thereby presenting significant opportunities in the field of drug delivery. However, despite extensive research efforts, no significant advances toward systematic in vivo studies or clinical applications have been achieved to date. In this Review, we outline the current state‐of‐the‐art of cargo encapsulation via PISA with a specific focus on developments achieved in the past 5 years. Considering the general requirements for functional drug delivery systems, we identify the major hurdles that still need to be overcome in order to push PISA‐derived systems from a promising academic exercise to viable candidates for clinical translation.

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Terpolymerization of Elemental Sulfur Waste with Propylene Oxide and Carbon Disulfide as a Strategy where Copolymerization fails

Gallizioli,

Battke,

Schlaad

et al. 2024

Preprint

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Elemental sulfur, a waste product of the oil refinement process, represents a promising raw material for the synthesis of degradable polymers. We show that simple lithium alkoxides facilitate the polymerisation of elemental sulfur S8 with industrially relevant propylene oxide (PO) and CS2 (a base chemical sourced from waste S8 itself) to give poly(monothiocarbonate-alt-Sx) in which x can be controlled by the amount of supplied sulfur. The in-situ generation of thiolate intermediates obtained by a rearrangement, which follows CS2 and PO incorporation, allows to combine S8 and epoxides into one polymer sequence that would otherwise not be possible. Mechanistic investigations reveal that alkyl oligosulfide intermediates from S8 ring opening and sulfur chain length equilibration represent the better nucleophiles for inserting the next PO if compared to the trithiocarbonates obtained from the competing CS2 addition, which causes the sequence selectivity. The polymers can be crosslinked in-situ with multifunctional thiols to yield reprocessable and degradable networks. Our report demonstrates how mechanistic understanding allows to combine intrinsically incompatible building blocks for sulfur waste utilisation.

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Kontrollierbare Zeitverzögerung beim Aufplatzen von oxidationsempfindlichen, mittels PISA synthetisierten Polymersomen

Cited by 3 publications

References 72 publications

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Polymerization‐induced self‐assembly for drug delivery: A critical appraisal

Terpolymerization of Elemental Sulfur Waste with Propylene Oxide and Carbon Disulfide as a Strategy where Copolymerization fails

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