Kontrastmittelfreie Mamma-MRT

Baltzer, Pascal; Kapetas, Panagiotis; Sodano, Claudia; Dietzel, Matthias; Pinker, Katja; Helbich, Thomas H.; Clauser, Paola

doi:10.1007/s00117-019-0524-7

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…DWI has enabled the identification of breast cancer particularly in dense breasts. However, the sensitivity of DWI tends to be variable compared to contrast-enhanced MRI [ 68 ]. Technical innovations are helping to overcome many of the image quality issues that have limited widespread use of DWI for breast [ 69 ].…”

Section: Techniques For Diagnosis or Detection Of Breast Cancermentioning

confidence: 99%

Current State of Breast Cancer Diagnosis, Treatment, and Theranostics

2021

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Breast cancer is one of the leading causes of cancer-related morbidity and mortality in women worldwide. Early diagnosis and effective treatment of all types of cancers are crucial for a positive prognosis. Patients with small tumor sizes at the time of their diagnosis have a significantly higher survival rate and a significantly reduced probability of the cancer being fatal. Therefore, many novel technologies are being developed for early detection of primary tumors, as well as distant metastases and recurrent disease, for effective breast cancer management. Theranostics has emerged as a new paradigm for the simultaneous diagnosis, imaging, and treatment of cancers. It has the potential to provide timely and improved patient care via personalized therapy. In nanotheranostics, cell-specific targeting moieties, imaging agents, and therapeutic agents can be embedded within a single formulation for effective treatment. In this review, we will highlight the different diagnosis techniques and treatment strategies for breast cancer management and explore recent advances in breast cancer theranostics. Our main focus will be to summarize recent trends and technologies in breast cancer diagnosis and treatment as reported in recent research papers and patents and discuss future perspectives for effective breast cancer therapy.

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Section: Techniques For Diagnosis or Detection Of Breast Cancermentioning

confidence: 99%

Current State of Breast Cancer Diagnosis, Treatment, and Theranostics

2021

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“…The EUSOBI recommends the basic protocol for breast MRI in addition to a diffusion-weighted sequence (DWI), which is already widely available internationally [9,37]. DWI visualizes the Brownian motion of water molecules in the extracellular space and thus provides insight into the microstructure of the tissue [37,38]. Clinical DWI protocols should include only two b-values (0 or 50 and 800 s/mm 2 ).…”

Section: Diffusion-weighted Imaging (Dwi)mentioning

confidence: 99%

Evidence-Based and Structured Diagnosis in Breast MRI using the Kaiser Score

Baltzer

Krug

Dietzel

2022

Rofo

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Background Breast MRI is the most sensitive method for the detection of breast cancer and is an integral part of modern breast imaging. On the other hand, interpretation of breast MRI exams is considered challenging due to the complexity of the available information. Clinical decision rules that combine diagnostic criteria in an algorithm can help the radiologist to read breast MRI by supporting objective and largely experience-independent diagnosis. Method Narrative review. In this article, the Kaiser Score (KS) as a clinical decision rule for breast MRI is introduced, its diagnostic criteria are defined, and strategies for clinical decision making using the KS are explained and discussed. Results The KS is based on machine learning and has been independently validated by international research. It is largely independent of the examination technique that is used. It allows objective differentiation between benign and malignant contrast-enhancing breast MRI findings using diagnostic BI-RADS criteria taken from T2w and dynamic contrast-enhanced T1w images. A flowchart guides the reader in up to three steps to determine a score corresponding to the probability of malignancy that can be used to assign a BI-RADS category. Individual decision making takes the clinical context into account and is illustrated by typical scenarios. Key Points: Citation Format

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“…However, it must be noted that there is currently no recommendation for using DWI for screening. The variations in diagnostic accuracy between studies can be attributed to the highly heterogeneous image quality of DWI 50 . The EUSOBI is currently discussing the possibility of using DWI for supplementary screening in patients with a high/intermediate risk profile, but there is currently not yet a recommendation in this regard.…”

Section: Dwi For Breast Cancer Screening Without Contrastmentioning

confidence: 99%

“…Es muss jedoch beachtet werden, dass zum aktuellen Zeitpunkt noch keine Empfehlung zum Screening mit der DWI existiert. Die zwischen den Studien schwankende diagnostische Genauigkeit wird auf die sehr heterogene Bildqualität der DWI zurückgeführt 50 . Die EUSOBI diskutiert derzeit die Möglichkeit der Anwendung der DWI in einem „supplementary screening“ in Patientinnen mit hohem/intermediären Risikoprofil, aber es existiert noch keine Empfehlung diesbezüglich.…”

Section: Dwi Zum Nativen Mammakarzinom-screeningunclassified

DWI of the Breast – Possibilities and Limitations

Meyer¹,

Martin²,

Denecke³

2022

Rofo

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Background The MRI of the breast is of great importance in the diagnosis of disorders of the breast. This can be stated for the primary diagnosis as well as the follow up. Of special interest is diffusion weighted imaging (DWI), which has an increasingly important role. The present review provides results regarding the diagnostic and prognostic relevance of DWI for disorders of the breast. Methods Under consideration of the recently published literature, the clinical value of DWI of the breast is discussed. Several diagnostic applications are shown, especially for the primary diagnosis of unclear tumors of the breast, the prediction of the axillary lymph node status and the possibility of a native screening. Moreover, correlations between DWI and histopathology features and treatment prediction with DWI are provided. Results Many studies have shown the diagnostic value of DWI for the primary diagnosis of intramammary lesions. Benign lesions of the breast have significantly higher apparent diffusion coefficients (ADC values) compared to malignant tumors. This can be clinically used to reduce unnecessary biopsies in clinical routine. However, there are inconclusive results for the prediction of the histological subtype of the breast cancer. DWI can aid in the prediction of treatment to neoadjuvant chemotherapy. Conclusion DWI is a very promising imaging modality, which should be included in the standard protocol of the MRI of the breast. DWI can provide clinically value in the diagnosis as well as for prognosis in breast cancer. Key Points: Citation Format

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Kontrastmittelfreie Mamma-MRT

Cited by 12 publications

References 29 publications

Current State of Breast Cancer Diagnosis, Treatment, and Theranostics

Current State of Breast Cancer Diagnosis, Treatment, and Theranostics

Evidence-Based and Structured Diagnosis in Breast MRI using the Kaiser Score

DWI of the Breast – Possibilities and Limitations

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