This article aims to construct a science based on the thought of Sastrajendra Hayuningrat Pangruwating Diyu. This article uses the method of a pashalik's spiritual journey consisting of three stages, namely mortal life, the "death" phase, and the real-life after "death", and is based on the Nusantara Paradigm. This construction changes the form of future science, which has a different dimension from modern science that only emphasizes material goals. The purpose of the science that will be taught is to return to God, which is the true goal. Manners are the main thing in transforming civilization, so it must be instilled in the process of teaching science. The teaching method uses various dimensions both physical and spiritual. The cognitive process is based on mental cultivation, taste, and meditation, and reflexivity.