Konservative katarakttherapie in klinik und experiment

Koch, H.-R.; Ebertz, Kurt-Helmut; Hockwin, O.

doi:10.1007/bf00177115

Cited by 6 publications

(3 citation statements)

References 105 publications

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“…Attempts to influence the cataract by medical treatment have a long history [16,17]. Modern in-vitro investigations of the cataractous lens have given a new impluse to the search for a useful anti-cataract medication [18,19].…”

Section: Introductionmentioning

confidence: 99%

Clinical and physical measurements of the cataractous lens

Brom¹,

Kooijman²,

Blanksma³

1990

Doc Ophthalmol

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In connection with the clinical trial of an anti-cataract drug (Bendazac lysine) a number of examination methods were used to assess the progress of the cataract: slitlamp examination, visual acuity determination, and the measurement of the contrast sensitivity, light scatter in the eye and the autofluorescence and transmission of the lens. In this article the measurements of 43 patients (43 eyes) are presented, taken at the time that medication was started. In this way we can get an impression of the value of these measurements for the study of cataractous lenses. The contrast sensitivity of the cataractous eye is lowered for all spatial frequencies as compared with the normal population. Light scatter is greatly increased. The autofluorescent profile of the lens with nuclear cataract differs markedly from that of the lens with cortical cataract.

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Section: Introductionmentioning

confidence: 99%

Clinical and physical measurements of the cataractous lens

Brom¹,

Kooijman²,

Blanksma³

1990

Doc Ophthalmol

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“…The review of Sanders et al [1987] makes clear that in most studies visual acuity was used as an index for cataract evolution (or progression); this is not the best method for the clinical assessment of such changes [Koch, 1982]. Only the investigation by Penne et al [ 1987] is based on hard data eval uation by TV recording of the lens images with a slit-lamp and digital processing.…”

Section: Introductionmentioning

confidence: 99%

“…The literature contains multiple reports about various drug effects in cataract treat ment [Koch, 1982;Koch et al, 1973], but only very few clinical trials have been performed with relevant, objective methods to permit a measurement-based decision about the effi cacy of anticataract drugs [Hockwin, 1983a, b;Hockwin et al, 1982b;Weigelin, 1982;Weigelin and Hockwin, 1982;Weigelin et al, 1982;Mayer and Irion, 1985;Mayer and König, 1987] as recommended by the WHO [1975,1985]. Thus, most of the available reports in the literature are not suit able for establishing drug efficacy.…”

Section: Introductionmentioning

confidence: 99%

Bendazac Lysine in Selected Types of Human Senile Cataract

Hockwin

Laser²,

Gregorio³

et al. 1989

Ophthalmic Res

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A double-masked placebo-controlled clinical trial with hard data evaluation by image analysis of Scheimpflug photographs taken at baseline and 6, 12 and 18 months after starting treatment was performed to assess the efficacy of bendazac lysine in four different types of senile cataract. The study had a classical split-plot design. For statistical evaluation, the analysis of variance and covariance for repeated measures were used for three different lens sections: anterior capsule and superficial layer, anterior cortex and nucleus. In the entire group of 53 evaluable patients (without separation into cataract-type subgroups), there was a significantly less increase over time in light scattering (i.e. film blackening) of the anterior cortex and nucleus with bendazac lysine than with placebo. There was also a strong trend in favour of the active drug at the anterior capsular level. Patients with water clefts and spokes showed a significantly less light scattering of the anterior capsule and cortex when treated with bendazac lysine. Those with nuclear changes also showed significantly less light scattering of the anterior cortex and nuclear region with the active drug than with placebo. The number of patients with subcapsular and wedge-shaped (cuneiform) cataracts was too small to be adequately assessed by statistical procedures. Nevertheless, there were indications of a beneficial effect of bendazac lysine on all the lens sections in patients with subcapsular cataracts and on the anterior cortical region in those with wedge-shaped cataracts. In conclusion, this study showed that the increase in light scattering over time, i.e. the progression of cataract, is less in bendazac lysine-treated patients than in those treated with placebo.

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Variation of Stump Volume After Below-Knee Amputation

Isherwood¹

1974

The Lancet

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Konservative katarakttherapie in klinik und experiment

Cited by 6 publications

References 105 publications

Clinical and physical measurements of the cataractous lens

Clinical and physical measurements of the cataractous lens

Bendazac Lysine in Selected Types of Human Senile Cataract

Variation of Stump Volume After Below-Knee Amputation

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