Kombinierte Knochenmark- und Skelettszintigraphie bei ossären und myelogenen Erkrankungen

Abstract

In 87 patients with proved diagnosis and a normal or pathologic bone scan (BS) in addition a bone marrow scan (BMS) was performed using a 99mtechnetium-labelled microcolloid. The analysis of scintigraphic findings included those obtained by other investigations shows that in these selected patients a false normal or false positive interpretation would have been resulted in 18% performing the BS only. Both methods BS and BMS were capable of diagnosing the correct stage of disease in all patients. The results indicate an augmentation of diagnostic facilities by the BMS in diseases affecting bone or bone marrow.

The value of bone scintigraphy, bone marrow scintigraphy and fast spin-echo magnetic resonance imaging in staging of patients with malignant solid tumours: a prospective study

“…Hence we cannot support the conclusions of Otsuka et al [32], who found BMS useful in distinguishing metastatic lesions from benign degenerative bone marrow changes in cases with suspected malignant bone involvement. Our findings are also at variance with those of Hotze et al [33], who recommended additional BMS in the case of equivocal BS to ascertain the diagnosis of metastases. Compared to BMS, MRI is much more specific as it can identify focal fatty conversion and differentiate this condition from metastatic marrow infiltration (Fig.…”

Recent advances in bone marrow scanning

“…After intravenous injection, 99mTc-nanocolloid is rapidly cleared from plasma and taken up by the RHS (Hotze et al 1984a). About 15%-20% of the injected dose is accumulated in the bone marrow by subendothelial macrophages (Hotze et al 1984a}, the rest being distributed mainly to the liver (70%) and spleen (10%) (ICRP 1989).…”

“…The mechanisms involved are microcolloid extravasation and -conceivably -phagocytosis by tissue macrophages or in vivo labelling of granulocytes infiltrating the inflammatory sites (Hotze et al 1984a;De Schrijver etal. The mechanisms involved are microcolloid extravasation and -conceivably -phagocytosis by tissue macrophages or in vivo labelling of granulocytes infiltrating the inflammatory sites (Hotze et al 1984a;De Schrijver etal.…”

“…In multiple myeloma, most authors found peripheral expansion on radiocolloid marrow scans (Hotze et al 1984a(Hotze et al , 1989Kessel etal. 1987;Ranner et al 1987;Munz 1984).…”

“…Radiocolloid scans might provide indi- Table 3. Bone marrow expansion would have to be differentiated then from purely "reactive expansion" which is often seen in benign disease such as infections (Hotze et al 1984a;Datz and Taylor 1985) or secondary due to "central depletion" (Datz and Taylor 1985). Diffusely reduced TcNCAA bone marrow uptake and multiple larger marrow defects in advanced multiple myeloma rect evidence of spread of "infiltrated tissue" (Dewes et al 1987).…”