Kolaviron Protects the Prefrontal Cortex and Hippocampus against Histomorphological and Neurobehavioural Changes in Cuprizone Model of Multiple Sclerosis

Omotoso, Gabriel Olaiya; Olajide, Olayemi Joseph; Gbadamosi, Ismail Temitayo; Rasheed, Mikail Abiodun; Izuogu, Chiazokam Tochukwu

doi:10.21315/mjms2018.25.2.6

Cited by 7 publications

(11 citation statements)

References 26 publications

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“…The administration of kolaviron was able to reverse the activities of SOD and GPx and malondialdehyde concentration to the range of controls. This finding corroborates our earlier report that kolaviron protects against ROS and their subsequent cellular damage in the brain (Omotoso et al., 2018b). This protective effect of kolaviron could be as a result of its intrinsic antioxidant activity (Farombi et al., 2004).…”

Section: Discussionsupporting

confidence: 93%

“…The mice were grouped into 4, with each group having 6 mice. Group A: Control, received regular diet; Group B: received kolaviron (200 mg/kg/d) (Omotoso et al., 2017, 2018a; 2018b) in addition to their regular diet; Group C: received 0.2% cuprizone diet only; while Group D: received a combination of kolaviron (200 mg/kg/d) and 0.2% cuprizone diet. The mice were monitored closely throughout the 35 days treatment.…”

Section: Methodsmentioning

confidence: 99%

“…Various works have used different doses of kolaviron, such as 100 mg/kg, 200 mg/kg and 400 mg/kg (Ayepola et al., 2013; Farombi et al., 2013, 2018; Olajide et al., 2016; Alabi et al., 2017; Omotoso et al, 2017, 2018a, 2018b). Many of these studies reported that both 100 mg/kg and 200 mg/kg doses have beneficial effects, with effective antioxidant and anti-inflammatory properties, amongst other potentials (Ayepola et al., 2013; Farombi et al., 2013, 2018; Olajide et al., 2016; Omotoso et al., 2018a, 2018b), but no reference was made to adverse effects of kolaviron on body organs at these doses. However, with the use of doses as high as 400 mg/kg, Alabi et al.…”

Section: Introductionmentioning

confidence: 99%

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Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

Omotoso

Olajide

Gbadamosi

et al. 2019

Heliyon

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Cuprizone-induced neurotoxicity has been employed to study the biology of remyelination in experimental models of multiple sclerosis. This study was aimed at determining the role of kolaviron, a biflavonoid from Garcinia kola, in mitigating the damaging effects of cuprizone on behaviour and the hippocampus. Twenty-four male albino mice aged 6-8 weeks were categorised into 4 equal groups: Group A (Control) received regular diet; Group B received 200 mg/kg/d of kolaviron in addition to their regular diet; Group C received 0.2% cuprizone diet only, while Group D received both kolaviron and cuprizone diet. The treatment lasted for 35 days after which behavioural tests (Morris water maze, Y maze and open field tests) were conducted and brain tissues were processed for histology, histochemistry (Nissl staining), immunohistochemistry (glial fibrillary acidic protein) and biochemistry (malondialdehyde, superoxide dismutase and glutathione peroxidase). Results showed that cuprizone toxicity led to weight loss, impairment in memory and exploratory drive, oxidative stress, chromatolysis and reactive astrocytosis; meanwhile administration of kolaviron prevented cuprizone-induced weight loss, memory decline, oxidative stress and neuromorphological alterations. In conclusion, administration of kolaviron might be useful in limiting the effects of cuprizone toxicity on the morphology and functions of the hippocampus.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

Omotoso

Olajide

Gbadamosi

et al. 2019

Heliyon

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“…Kolaviron ( Figure 8 ), a biflavonoid (a complex of two compounds), has been identified as the active compound in the seed of Garcinia kola , known for its neuroprotective [ 135 ], cardioprotective [ 136 ], hepatoprotective and protective kidney activities [ 137 ]. Kolaviron (100 and 200 mg/kg, p.o., rat) showed a potential gastroprotective activity in different experimental models of peptic ulcer: immobilization and cold stress, NSAIDs, ethanol, pyloric ligation, and ischemia-reperfusion.…”

Section: Resultsmentioning

confidence: 99%

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

et al. 2020

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Peptic ulcers are characterized by erosions on the mucosa of the gastrointestinal tract that may reach the muscle layer. Their etiology is multifactorial and occurs when the balance between offensive and protective factors of the mucosa is disturbed. Peptic ulcers represent a global health problem, affecting millions of people worldwide and showing high rates of recurrence. Helicobacter pylori infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most important predisposing factors for the development of peptic ulcers. Therefore, new approaches to complementary treatments are needed to prevent the development of ulcers and their recurrence. Natural products such as medicinal plants and their isolated compounds have been widely used in experimental models of peptic ulcers. Flavonoids are among the molecules of greatest interest in biological assays due to their anti-inflammatory and antioxidant properties. The present study is a literature review of flavonoids that have been reported to show peptic ulcer activity in experimental models. Studies published from January 2010 to January 2020 were selected from reference databases. This review refers to a collection of flavonoids with antiulcer activity in vivo and in vitro models.

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“…Kolaviron is a natural antioxidant and anti-inflammatory bioflavonoid isolated from Garcinia kola [15][16][17]. It is used as a management regimen for several infections and disease conditions due to its acclaimed antiviral, antibacterial, antifungal, anti-inflammatory and antioxidant activities [18,19].…”

Section: Original Articlementioning

confidence: 99%

Kolaviron protects against cognitive deficits and cortico-hippocampal perturbations associated with maternal deprivation in rats

et al. 2020

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Prolonged separation of pups from their mother in early postnatal period can interfere with normal growth and development, resulting in different behavioral changes similar to features of schizophrenia in man. This study explored the cytoprotective action of kolaviron, a biflavonoid, on the prefrontal cortex and hippocampus of maternally deprived Wistar rats. Eight months old female rats were time-mated, and after delivery their pups were randomly assigned into four groups; group A received 0.5 ml of normal saline, group B received kolaviron orally (200 mg/kg/bw) on postnatal days (PND) 21-35, group C were maternally deprived on PND 9 for 24 hours, while group D were also maternally deprived on PND 9 for 24 hours, and then received kolaviron orally (200 mg/kg/bw) on PND 21-35. Behavioral studies (open field test, Morris water test, and Y-maze test) were conducted after the experiment prior to sacrifice. Some of the rats were anesthetized with ketamine and perfusion-fixed with 0.1 M phosphate buffered saline and 4% paraformaldehyde, while others were sacrificed by cervical dislocation for enzyme studies. The hippocampus and prefrontal cortex were excised from the brain and processed for tissue histology, histochemistry, and enzymatic analysis. Results revealed behavioral deficits, oxidative stress, degenerative changes, and astrocytosis in the prefrontal cortex and hippocampus of maternally deprived rats, but intervention with kolaviron caused significant improvement in neurobehavior, morphology, and neurochemistry in these brain areas. We concluded that kolaviron could protect the brain against neurological consequences of nutritional and environmental insults arising from maternal separation in early postnatal period.

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Kolaviron Protects the Prefrontal Cortex and Hippocampus against Histomorphological and Neurobehavioural Changes in Cuprizone Model of Multiple Sclerosis

Cited by 7 publications

References 26 publications

Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020)

Kolaviron protects against cognitive deficits and cortico-hippocampal perturbations associated with maternal deprivation in rats

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