Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: The implications for neuroendopathobiological changes during chemotherapy

Oyovwi, Mega O.; Ben‐Azu, Benneth; Edesiri, Tesi P.; Emojevwe, Victor; Rotu, Rume A.; Ozegbe, Queen E.B.; Nwangwa, Eze Kingsley; Atuadu, Vivian; Adebayo, Olusegun G.

doi:10.1016/j.biopha.2021.112022

Cited by 23 publications

(30 citation statements)

References 68 publications

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“…Busulfan: a 1,4‐Butanediol dimethanesulfonate was dissolved with DMSO as a vehicle based on our previous study where it was insoluble in saline (Oyovwi, Ben‐Azu, Edesiri, et al., 2021), both products were obtained from Sigma, St. Louis, USA. Further, the same volume of de‐ionized water (1:1) was added to obtain the final 5 mg/ml concentration and each animal was administered based on individual body weight.…”

Section: Methodsmentioning

confidence: 99%

“…Also, other mechanisms centered around neuroinflammation and altered apoptosis‐related processes have also been suggested in busulfan‐induced chemo‐brain (Mohammadghasemi et al., 2008; Nasimi et al., 2015; Seigers & Fardell, 2011). Given this background, it has been previously revealed that improving the quality of life of cancer patients under chemotherapy requires the use of antioxidant, anti‐inflammatory, and neuroprotective compounds (Jung et al., 2015; Nasimi et al., 2018; Oyovwi, Ben‐Azu, Edesiri, et al., 2021; Suriapraba et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, these findings raise the potential benefits of KV extract in busulfan‐mediated oxidative, inflammatory, and apoptotic‐induced neuroendopathobiological derangements. As part of our search for extracts that could mitigate against the adverse effects induced by chemotherapeutic drugs on reproductive and brain health, as well as our previous studies (Oyovwi, Ben‐Azu, Edesiri, et al., 2021) on busulfan and KV, this present study was designed to elucidate the underlying mechanisms of KV extract in busulfan‐induced chemo‐brain and testicular damage in mice.…”

Section: Introductionmentioning

confidence: 99%

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Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory, and apoptotic pathways

Tesi

Ben‐Azu

Mega

et al. 2022

Journal of Food Biochemistry

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Previous reports revealed that increased oxidative stress with up-regulated inflammatory proteins and apoptotic factors have serious implications in busulfan-induced chemo-brain and testicular damages. Hence, we investigated the potential reversal effects of kolaviron (KV), a neuro-active extract rich in flavonoids with proven antioxido-inflammatory and anti-apoptotic properties, on busulfan-induced oxidative damage, inflammatory proteins, and apoptosis in the brains and testes of male rats. In the treatment-regimen, animals in groups 1 and 2 had saline (10 ml/kg/p.o./day) and dimethyl sulfoxide (DMSO; 10 ml/kg/p.o./day), group 3 received KV extract (200 mg/ kg/p.o./day), group 4 was given busulfan (50 mg/kg/p.o./day) and animals in group 5 were pretreated with busulfan (50 mg/kg/p.o./day) successively for 56 days in addition to KV extract (200 mg/kg/p.o./day) from days 29-56. Non-spatial memory function was valuated with a novel-object recognition memory test. Thereafter, testicular and brain oxidative/antioxidant status, proinflammatory-and apoptotic-related proteins, testicular enzymatic markers were evaluated respectively. Kolaviron extract improved cognitive function by increasing exploration of novel-object of busulfantreated rats. Kolaviron extract reversed busulfan-mediated increased malondialdehyde, 8-hydroxy-2′-deoxyguanosine, and decreased superoxide dismutase, catalase, glutathione, and glutathione-peroxidase in brains and testes as well as the testicular enzyme markers. Increased brain and testicular weights, and TNFα, IL-1β, and NFκβ productions due to busulfan administration were also reduced by the extract.The reduced testicular B-cell lymphoma-2, sperm mitochondrial cytochrome-C, and membrane potential, increased DNA fragmentation, caspases -3 and -9 levels were also profoundly reversed by KV. Additionally, KV extract ameliorated busulfaninduced testicular histopathological changes in rats. Conclusively, KV extract reverses busulfan-induced neuroendopathobiological derangements via oxidative stress inhibition, down-regulation of inflammatory and apoptotic mediators in rats' brains and testes.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory, and apoptotic pathways

Tesi

Ben‐Azu

Mega

et al. 2022

Journal of Food Biochemistry

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“…Cancer patients will have a series of cognitive changes after chemotherapy, among which memory impairment was one of the main performances (25). Kanaskie et al (26) believes that the changes in cognitive function are the side effects after chemotherapy for some breast cancer survivors, which include subtle changes in memory, attention, and executive function.…”

Section: Discussionmentioning

confidence: 99%

“…Cancer patients will have a series of cognitive changes after chemotherapy, among which memory impairment was one of the main performances ( 25 ). Kanaskie et al.…”

Section: Discussionmentioning

confidence: 99%

The COMT Genetic Factor Regulates Chemotherapy-Related Prospective Memory Impairment in Survivors With HER2−/+ Breast Cancer

Zhang

Cai

et al. 2022

Front. Oncol.

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BackgroundPrevious findings indicated that polymorphism in gene catechol-O-methyltransferase (COMT) had been linked to chemotherapy-related cognitive impairment (CRCI). Nevertheless, the motivation of COMT polymorphisms in regulating cognitive impairment in breast cancer survivors with disparate status of human epidermal growth factor receptor 2 (HER2) was still vague.ObjectiveThe current research aimed to evaluate the regulation of the risk by COMT genotype on CRCI in breast cancer survivors with disparate status of HER2.MethodsBreast cancer survivors (103 with HER2− and 118 with HER2+) underwent neuropsychological tests before and after chemotherapy, containing event- and time-based prospective memory (EBPM and TBPM). Three single-nucleotide polymorphisms (SNPs) were estimated by providing peripheral blood, containing COMT (rs165599, rs737865, and rs4680).ResultsThe EBPM and TBPM performances was lower as compared with these before chemotherapy (z = −7.712, z = −2.403, respectively, p < 0.01). Furthermore, the EBPM and TBPM performances of HER2− group survivors were lower than those of HER2+ group survivors after chemotherapy (z = −7.181, p < 0.01; z = −2.205 p < 0.05, respectively). The survivors with COMT (rs165599) A/A genotype carriers had a meaningfully poorer chance of memory descend [dominant model: adjusted, OR = 2.21, CI (95%) = 1.156–4.225, p = 0.016] and showed better on TBPM test, relative to G/G genotype. Patients with the COMT (rs737865) A/G and G/G genotype showed protective function than the patients with the A/A and performed better on MMSE and TBPM tests.ConclusionThe types of HER2 may be correlated to chemotherapy-related prospective memory impairments in breast cancer survivors. Furthermore, the COMT (rs165599, rs737865) polymorphisms were correlated to the risk of TBPM decline scores and possibly be a potential genetic identifying for increasing risk of CRCI in breast cancer patients with disparate status of HER2.

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D-ribose-L-cysteine exhibits restorative neurobehavioral functions through modulation of neurochemical activities and inhibition oxido-inflammatory perturbations in rats exposed to polychlorinated biphenyl

Oyovwi,

Ben-Azu,

Falajiki

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: The implications for neuroendopathobiological changes during chemotherapy

Cited by 23 publications

References 68 publications

Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory, and apoptotic pathways

Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory, and apoptotic pathways

The COMT Genetic Factor Regulates Chemotherapy-Related Prospective Memory Impairment in Survivors With HER2−/+ Breast Cancer

D-ribose-L-cysteine exhibits restorative neurobehavioral functions through modulation of neurochemical activities and inhibition oxido-inflammatory perturbations in rats exposed to polychlorinated biphenyl

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