Kojic Acid Derivatives

Abstract

Medicinal Chemistry and Drug Design 2 browning in fruits and vegetables. In the food industry, tyrosinase is important in controlling the quality and economics of fruits and vegetables. Hence, tyrosinase inhibitors from natural sources have great potential in the food industry, as they are considered to be safe and largely free from adverse effects. Also in insects, tyrosinase is involved in melanogenesis wound healing, parasite encapsulation and sclerotisation (Seo, 2003). Therefore, tyrosinase inhibitors used as insecticides and insect control agents. Moreover, the tyrosinase is responsible from melanization in animals and is the key enzyme for the regulation of melanogenesis in mammals. Melanogenesis is the process by which melanin is produced and subsequently distributed by melanocytes within the skin and hair follicles. This process results in the synthesis of melanin pigments, which play a protective role against skin photocarcinogenesis (

Production of kojic acid by Aspergillus flavus OL314748 using box-Behnken statistical design and its antibacterial and anticancer applications using molecular docking technique

“…kojic acid was found not toxic in reproductive, chronic, genotoxicity, and acute studies due to its slowly releasing properties throughout the human skin [ 93 , 94 ]. The toxicity of kojic acid is connected basically with the concentration [ 93 ].…”

Synthesis and Some Properties of New 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones

“…Kojic acid 1 (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) is widely used in the pharmaceutical industry, agrochemistry, cosmetology [1][2][3][4][5], and as a ligand for complex compounds [6] and building blocks for construction of biologically active heterocyclic molecules [7][8][9]. Being one of the most studied and available non-toxic tyrosinase inhibitors [10,11], kojic acid as a bioactive molecule is not devoid of disadvantages, among which should be noted the lack of stability during storage and a relatively low inhibitory activity.…”

Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging—Preliminary Study

“…Kojic acid captures copper ions, preventing the activation of tyrosinase, thus preventing the formation of melanin [ 12 , 14 ]. Due to its tyrosinase-inhibiting activity, KA is considered one of the most effective skin lightening agents in the beauty industry [ 15 ]. Kojic acid is a hydrophilic molecule containing a reactive gamma-pyrone ring with weak acidity.…”