Kojic acid derivatives as double face ligands for metal and phosphate ions.

Study of the DNA binding mechanism and in vitro activity against cancer cells of iron(iii) and aluminium(iii) kojic acid derivative complexes

“…25 Pyrophosphate ions (PPi) form adducts with the S2 ligand by the formation of hydrogen bonds with KA units and the linker. 28 Importantly, PPi has also high affinity to iron(III) and aluminium(III) ions. In the mixture containing equimolar concentrations of S2, metal and PPi, different species will be formed.…”

“…Recently, we presented a series of KA derivatives with the ability to bind different metal ions (essential: Fe 3+ , Cu 2+ , Zn 2+ ; and toxic: Al 3+ ) contemporarily or interchangeably with phosphate ions (monophosphate, pyrophosphate and tripolyphosphate). The stability constant analysis 25,26 allows us to predict the formation of Fe 3+ -ligandanion and Al 3+ -ligand-anion complexes, which could also be formed with DNA, thus presenting a novel class of metallodrugs in anticancer therapy.…”

A Comparative DFT Study on the Antioxidant Activity of Some Novel 3‐Hydroxypyridine‐4‐One Derivatives

“…It is also applied in the cosmetics industry as a skin lightener thanks to its tyrosinase‐inhibiting effect [25,28–29] . Kojic acid is a member of the α‐hydroxypyrone family, commonly known as effective chelators of many metal ions [30,31] . The ability to chelate iron is also shown by the α‐hydroxyketone moiety [31,32] .…”

“…Kojic acid is a member of the α‐hydroxypyrone family, commonly known as effective chelators of many metal ions [30,31] . The ability to chelate iron is also shown by the α‐hydroxyketone moiety [31,32] . A special case of very effective iron ion chelators are the hydroxypyridinones – the products of reaction of hydroxypyranone with primary amines [33] .…”

“…[30,31] The ability to chelate iron is also shown by the α-hydroxyketone moiety. [31,32] A special case of very effective iron ion chelators are the hydroxypyridinones -the products of reaction of hydroxypyranone with primary amines. [33] Thanks to these qualities, they are widely used in the therapy of thalassemia -especially 1,2dimethyl-3-hydroxy-pyridin-4-one, known as deferiprone L1 chelator.…”