Kojic acid and its manganese and zinc complexes as potential radioprotective agents

Emami, Saeed; Hosseinimehr, Seyed Jalal; Taghdisi, Seyed Mohammad; Akhlaghpoor, Shahram

doi:10.1016/j.bmcl.2006.09.097

Cited by 100 publications

(63 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[21][22][23] In addition, Zn(II) complexes are often utilized in many fields such as radioprotection, 24 antidiabetic insulinmimemetism, 25,26 antibacterial or antimicrobial agents, [27][28][29] tumour photosensitizers 30 and binder complexes at DNA sites [31][32][33][34] . The development of metal chelators for the attenuation of metalinvolved neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative diseases are matters of current interest.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of some water soluble Zn(ii) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA

et al. 2014

View full text Add to dashboard Cite

The synthesis and spectroscopic properties of nine water soluble zinc(II) complexes of (E)-N-(pyridin-2-ylmethylene)arylamines (Ln) with the general formula [Zn(X)2(Ln)] (X = Cl−, Br−, I−; (1-8)) and [Zn(-N3)-(N3)(L3)]2 (9) are reported. The complexes were characterized by elemental analysis and their spectroscopic properties were studied using UV-Visible, fluorescence, IR and 1H NMR spectroscopies. The solid state structures of zinc(II) complexes 2-4 and 6-9 were established by single crystal X-ray crystallography. The majority of the structures are mononuclear with tetra-coordinate zinc centres (2-4, 6 and 7) except where L carries an additional donor atom capable of coordinating zinc (8), in which case the zinc atom has a distorted square pyramidal geometry. The centrosymmetric molecule of [Zn(-N3)(N3)(L3)]2 (9) is binuclear with the zinc atoms in a trigonal bipyramidal coordination environment. In general, the dichlorozinc derivatives 1, 3-5 and 8 exhibited moderately elevated in vitro cytotoxic potency towards the human epithelial cervical carcinoma (HeLa) cell line, with 4 as the best performer (IC50 value of 18 M). Apoptosis-inducing activity, assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, showed that the zinc complexes interacted with DNA and thereby interfered the DNA binding of several transcription factors to its promoter sites, thus inhibiting gene transcription required for the biological activity of cells. Accepted ManuscriptThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, which is prior to technical editing, formatting and proof reading. This free service from RSC Publishing allows authors to make their results available to the community, in citable form, before publication of the edited article. This Accepted Manuscript will be replaced by the edited and formatted Advance Article as soon as this is available.To cite this manuscript please use its permanent Digital Object Identifier (DOI®), which is identical for all formats of publication.More information about Accepted Manuscripts can be found in the Information for Authors.Please note that technical editing may introduce minor changes to the text and/or graphics contained in the manuscript submitted by the author(s) which may alter content, and that the standard Terms & Conditions and the ethical guidelines that apply to the journal are still applicable. In no event shall the RSC be held responsible for any errors or omissions in these Accepted Manuscript manuscripts or any consequences arising from the use of any information contained in them. www.rsc.org/dalton ISSN 1477-9226 Dalton TransactionsAn international journal of inorganic chemistry 1477-9226(2010)

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of some water soluble Zn(ii) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA

et al. 2014

View full text Add to dashboard Cite

show abstract

“…It has been indicated that kojic acid has properties of radioprotectors (Emami et al, 2007;Hosseinimehr et al, 2009) and antioxidants and can stimulate the neutrophilic granulocyte phagocytosis and lymphocyte proliferation (Niwa and Akamatsu, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that KA can protect skin from pigmentation (Chisvert et al, 2010;Kwak et al, 2011) and can suppress enzymatic browning of fruits, raw shrimps and crabs (Nohynek et al, 2004), and is widely utilized in cosmetics and food processing areas. Moreover, recent literature has examined potential pharmacological effects, including radioprotective (Emami et al, 2007;Hosseinimehr et al, 2009), anti-HIV reverse transcriptase (Tanaka et al, 2009), anti-diabetic (Wei et al, 2011) and anti-convulsant (Aytemir et al, 2010) for KA and its derivatives apart from the above properties. Emami S. et al studied the radioprotective effects in male NMRI mice for KA with pretreatment 24 h before exposed to a lethal dose of gamma irradiation (Emami et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, recent literature has examined potential pharmacological effects, including radioprotective (Emami et al, 2007;Hosseinimehr et al, 2009), anti-HIV reverse transcriptase (Tanaka et al, 2009), anti-diabetic (Wei et al, 2011) and anti-convulsant (Aytemir et al, 2010) for KA and its derivatives apart from the above properties. Emami S. et al studied the radioprotective effects in male NMRI mice for KA with pretreatment 24 h before exposed to a lethal dose of gamma irradiation (Emami et al, 2007). Based on their findings, we carried out in vivo and in vitro experiments to further confirm the radioprotective effects of KA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kojic Acid Protects C57BL/6 Mice from Gamma-irradiation Induced Damage

Wang¹,

Liu²,

Di³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

The radioprotective effects of a single administration of kojic acid (KA) against ionizing radiation were evaluated via assessment of 30-day survival and alterations of peripheral blood parameters of adult C57BL/6 male mice. The 30-day survival rate of mice pretreated with KA (75 or 300 mg/kg body weight, KA75 or KA300) subcutaneously 27 h prior to a lethal dose (8 Gy, 153.52 cGy/min) of gamma irradiation was higher than that of mice irradiated alone (40% or 60% vs 0%). It was observed that the white blood cell (WBC) count/the red blood cell (RBC) count, haemoglobin content, haematocrit and platelet count of mice with or without KA pretreatment as exposed to a sub-lethal dose (4 Gy, 148.14 cGy/min) of gamma irradiation decreased maximally at day 4/day 8 post-irradiation. Although the initial WBC values were low in KA300 or WR-2721 (amifostine) groups, they significantly recovered to normal at day 19, whereas in the control group they did not. The results from the cytotoxicity and cell viability assays demonstrated that KA could highly protect Chinese hamster ovary (CHO) cells against ionizing radiation with low toxicity. In summary, KA provides marked radioprotective effects both in vivo and in vitro.

show abstract

“…At present, kojic acid is primarily used as the basic ingredient for excellent skin lightener in cosmetic creams, where it is used to block the formation of pigment by the deep cells on the skins (Masse et al 2001). In addition, kojic acid and its manganese and zinc complexes can potentially be used as radio protective agents, particularly against γ-ray ( Emami et al 2007). Recently, methods for the synthesis of various kojic acid derivatives, such as kojic acid ester, kojic acid laureate and kojic acid dipalmitate have been reported in many studies (Brtko et al 2004, Lee et al 2006, Khamaruddin et al 2008, Ashari et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Isolation and screening of kojic acid producing isolate of Aspergillus oryzae potentially applicable for production from sugarcane molasses

Rasmey¹,

Basha²

2016

IJBR

View full text Add to dashboard Cite

Kojic acid is an organic acid produced as secondary metabolite by different fungi specially Aspergillus species. Isolation of a novel fungal strain potential for kojic acid production from agro-industrial wastes was the main purpose of the present study. Kojic acid was estimated in the current investigation colorimetric by 2,6-dichlorophenolindophenol (DCIP). A total of 43 fungal isolates belonging to seven species of Aspergillus recovered from stored wheat grains and dust air were screened for their ability to produce kojic acid. Ten isolates of them belonging to A. oryzae and A. flavus var. columnaris produced high concentrations (16.818 ± 0.006 -43.917 ± 0.389 g/l) of kojic acid from glucose. The secondary screening of these ten isolates for kojic acid production from glucose, sucrose, starch, maltose and cellulose as different carbon sources resulted that A. oryzae 124A was the highly producer on glucose and sucrose recording 44.189 ± 0.079 and 32.135 ± 0.298 g/l, respectively. A. oryzae 124A produced 15.022 ± 0.017 g/l of kojic acid from the pretreated semisynthetic sugarcane molasses. The maximum concentration (29.431 ± 0.001 g/l) of kojic acid production by A. oryzae 124A from sugarcane molasses was obtained when the fungus grown on 5 % sugarcane molasses adjusted at pH 3.5 and incubated at 28 ∘ C for 19 days. The recorded results suggested that A. oryzae 124A could be used as a promising candidate for utilization in kojic acid fermentation from sugarcane molasses on industrial scale.

show abstract

Kojic acid and its manganese and zinc complexes as potential radioprotective agents

Cited by 100 publications

References 24 publications

Synthesis and characterization of some water soluble Zn(ii) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA

Synthesis and characterization of some water soluble Zn(ii) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA

Kojic Acid Protects C57BL/6 Mice from Gamma-irradiation Induced Damage

Isolation and screening of kojic acid producing isolate of Aspergillus oryzae potentially applicable for production from sugarcane molasses

Contact Info

Product

Resources

About