Koilocytes are enriched for alkaline-labile sites

Cortés‐Gutiérrez, Elva I.; Dávila-Rodríguez, Martha I.; Fernández, José Luis Fernández; López‐Fernández, Carmen; Gosálvez, Jaime

doi:10.4081/ejh.2010.e32

Cited by 10 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bi/multinucleation is strongly indicative of HPV infection [32] and, in this study, it is most frequent with LSIL or inferior histopathological outcome, but not significantly associated. On the other hand, hyperkeratosis showed a significantly higher frequency of prevalence for a severer histopathological result.…”

Section: Discussionmentioning

confidence: 53%

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Oliveira

Eleutério

et al. 2018

Acta Cytologica

View full text Add to dashboard Cite

Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women. Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Results: Enlarged nucleus was the most frequent ASC-US criterion, but alternative criteria were present in 20% of the total cases. No ASC-US criteria were associated with histological outcomes or HR-HPV positivity. Parakeratosis, corneal pearl, giant cells, and binucleation were strongly associated with ASC-US while hyperkeratosis was associated with high-grade squamous intraepithelial lesions (HSIL) or a superior outcome. HR-HPV was positive in 64.39% of ASC-US and 65.38% of ASC-H. HSIL or superior outcomes also occurred in 13.33% of ASC-US and 64.71% of ASC-H cases. Conclusion: Alternative criteria for ASC-US were relatively frequent. Reactive cellular changes suggestive of atypias were more abundant in ASC-US. Although ASC-H is associated with worse histological outcomes, no differences in HPV positivity were found in comparison to ASC-US.

show abstract

Section: Discussionmentioning

confidence: 53%

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Oliveira

Eleutério

et al. 2018

Acta Cytologica

View full text Add to dashboard Cite

show abstract

“…All these advances have made it possible to transfer basic biology and scientific knowledge to the clinical setting. 23 , 58-60 This has also revolutionized our way of thinking and studying the nucleus as a microenvironment that houses an integrated network of chemical reactions, where fine regulation and probability, combined with the contribution of external stimuli, allow the realization of specific transcriptional programs and cell phenotypes.…”

Section: Studying Nuclear Environment and Chromatin Dynamics From The...mentioning

confidence: 99%

Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry

et al. 2022

View full text Add to dashboard Cite

Since the discovery of DNA structure in 1953, the deoxyribonucleic acid has always been playing a central role in biological research. As physical and ordered nucleotides sequence, it stands at the base of genes existence. Furthermore, beside this 2-dimensional sequence, DNA is characterized by a 3D structural and functional organization, which is of interest for the scientific community due to multiple levels of expression regulation, of interaction with other biomolecules, and much more. Analogously, the nucleic acid counterpart of DNA, RNA, represents a central issue in research, because of its fundamental role in gene expression and regulation, and for the DNA-RNA interplay. Because of their importance, DNA and RNA have always been mentioned and studied in several publications, and the European Journal of Histochemistry is no exception. Here, we review and discuss the papers published in the last 60 years of this Journal, focusing on its contribution in deepening the knowledge about this topic and analysing papers that reflect the interest this Journal always granted to the world of DNA and RNA.

show abstract

“…In the last-three-years sample from the European Journal of Histochemistry , several articles concerned the search for one or more diagnostic and prognostic indicators specifically marking a given disease, 4–15 but other were focussed on experiments aimed at identifying the molecular bases of the pathogenetic process, 16–20 or at assessing the metastatic potential of tumour cell populations, 21,22 or at describing the effects of therapeutic interventions. 23–27 Most of these studies were performed by light (essentially conventional or confocal fluorescence) microscopy, but electron microscopy and ultrastructural immunohistochemistry has also been used for investigating functional changes in cells from different tissues or under different experimental conditions.…”

Section: A Survey Of the Recent Contents Of A Long-time Established Hmentioning

confidence: 99%

On the future contents of a small journal of histochemistry

Pellicciari

2012

Eur J Histochem

View full text Add to dashboard Cite

In the last three years, more than 70,000 scientific articles have been published in peer reviewed journals on the application of histochemistry in the biomedical field: most of them did not appear in strictly histochemical journals, but in others dealing with cell and molecular biology, medicine or biotechnology. This proves that histochemistry is still an active and innovative discipline with relevance in basic and applied biological research, but also demonstrates that especially the small histochemical journals should likely reconsider their scopes and strategies to preserve their authorship. A review of the last three years volumes of the European Journal of Histochemistry, taken as an example of a long-time established small journal, confirmed that the published articles were widely heterogeneous in their topics and experimental models, as in this journal's tradition. This strongly suggests that a journal of histochemistry should keep its role as a forum open to an audience as broad as possible, publishing papers on cell and tissue biology in a wide variety of models. This will improve knowledge of the basic mechanisms of development and differentiation, while helping to increase the number of potential authors since scientists who generally do not use histochemistry in their research will find hints for the applications of histochemical techniques to novel still unexplored subjects.

show abstract

Koilocytes are enriched for alkaline-labile sites

Cited by 10 publications

References 24 publications

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology

Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry

On the future contents of a small journal of histochemistry

Contact Info

Product

Resources

About