KNTC1 knockdown inhibits the proliferation and migration of osteosarcoma cells by MCM2
Lei Zhong,
Yuanwei Dong,
Shuqin Liu
Abstract:Osteosarcoma (OS) is a common primary malignant bone tumor, and it is necessary to further investigate the molecular mechanism of OS progression. The expression of kinetochore associated protein 1 (KNTC1) and minichromosome maintenance 2 (MCM2) was detected by immunohistochemistry, quantitative PCR (qPCR) and Western blot. Gene knockdown or overexpression cell models were constructed and the proliferation, apoptosis, cell cycle and migration were detected in vitro, besides, xenograft models were established to… Show more
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