Known Modifiable Risk Factors of Cancers

Justiz-Vaillant, Angel

doi:10.20944/preprints202212.0579.v1

Cited by 18 publications

(36 citation statements)

References 54 publications

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“…The incidence of aGVHD in patients with hematopoietic cell transplantation from HLA-matched siblings is 50% but the incidence is higher in unmatched donors [ 9 ]. Our patient had a haploidentical bone marrow transplant which put him at higher risk for GVHD and infections.…”

Section: Discussionmentioning

confidence: 99%

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BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

Jiffry¹,

Rangsipat²,

Tabares³

et al. 2023

Cureus

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The BK virus is a polyomavirus known to particularly affect transplant recipients. An important complication caused by BK virus infection in bone marrow transplant patients is hemorrhagic cystitis. We present a 31-year-old male with a history of bone marrow transplantation complicated by graft-versus-host disease (GVHD) and was diagnosed with BK virus-related hemorrhagic cystitis. He presented with gross hematuria and suprapubic and penile pain for one week. He has a significant past medical history of acute Bcell lymphocytic leukemia for which he has successfully undergone allogenic bone marrow transplantation, which was complicated by GVHD. Imaging revealed significant bladder wall thickening which prompted an evaluation for BK virus-induced hemorrhagic cystitis. A urinary specimen was sent for BK virus polymerase chain reaction (PCR) which was strongly positive, confirming the infection. He was managed supportively throughout his hospitalization and improved with symptomatic management alone. Our case demonstrates one of the main complications caused by the BK virus in allogeneic bone marrow transplant patients in the setting of GVHD and is an important differential to keep in mind when treating patients presenting with hematuria after bone marrow transplantation.

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Section: Discussionmentioning

confidence: 99%

“…Our patient had a haploidentical bone marrow transplant which put him at higher risk for GVHD and infections. While the incidence of chronic GVHD ranges from 6% to 80%, the morbidity and mortality due to GVHD after having hematopoietic cell transplantation is more than 10% [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

Jiffry¹,

Rangsipat²,

Tabares³

et al. 2023

Cureus

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“… 172 , 173 Further, people with SCI primarily suffer from common bacterial infections such as pneumonia and UTIs, 26 but not infections from opportunistic pathogens 174 , 175 seen in people with dysfunctional immune responses or immune deficiencies. 176 , 177 Continued research on the immune response to SCI and an emphasis on educating patients and providers on the prevention of common infections have the potential to significantly reduce infection rates in the future.…”

Section: Discussionmentioning

confidence: 99%

Species Differences in Blood Lymphocyte Responses After Spinal Cord Injury

Ayala

Fishman

Noyelle

et al. 2023

Journal of Neurotrauma

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People with spinal cord injury (SCI) get recurrent infections, such as urinary tract infections (UTIs) and pneumonias, that cause mortality and worsen neurological recovery. Over the past decades, researchers have proposed that post-SCI lymphopenia and decreased lymphocyte function increase susceptibility to infections and worsen neurological outcome in humans, leading to a condition called SCI-induced immune depression syndrome (SCI-IDS). In this review, we explore how SCI affects blood lymphocyte homeostasis and function in humans and rodents. Understanding how SCI affects blood lymphocytes will help the management of recurrent infections in spinal cord injured people and shed light on the clinical translation of findings in animal models to humans.

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“…Zinc is required for many enzymatic reactions related to innate and adaptive immunity, including antiviral defense mechanisms [ 52 ]. Accordingly, zinc deficiency results in a compromised immune system, with direct ramifications for immune cell function (B-cell, T-cell, and natural killer cell) [ 53 ]. Regarding COVID-19, serum zinc levels are lower in infected children [ 54 ] and adults [ 55 ] compared to non-infected individuals.…”

Section: Over/undernutrition Effects On Covid-19 and Pascmentioning

confidence: 99%

The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC

2023

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The expansive and rapid spread of the SARS-CoV-2 virus has resulted in a global pandemic of COVID-19 infection and disease. Though initially perceived to be acute in nature, many patients report persistent and recurrent symptoms beyond the infectious period. Emerging as a new epidemic, “long-COVID”, or post-acute sequelae of coronavirus disease (PASC), has substantially altered the lives of millions of people globally. Symptoms of both COVID-19 and PASC are individual, but share commonality to established respiratory viruses, which include but are not limited to chest pain, shortness of breath, fatigue, along with adverse metabolic and pulmonary health effects. Nutrition plays a critical role in immune function and metabolic health and thus is implicated in reducing risk or severity of symptoms for both COVID-19 and PASC. However, despite the impact of nutrition on these key physiological functions related to COVID-19 and PASC, the precise role of nutrition in COVID-19 infection and PASC onset or severity remains to be elucidated. This narrative review will discuss established and emerging nutrition approaches that may play a role in COVID-19 and PASC, with references to the established nutrition and clinical practice guidelines that should remain the primary resources for patients and practitioners.

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Known Modifiable Risk Factors of Cancers

Cited by 18 publications

References 54 publications

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

Species Differences in Blood Lymphocyte Responses After Spinal Cord Injury

The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC

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