Knowledge, understanding, and uptake of noninvasive prenatal testing among Latina women

Farrell, Rachel; Hawkins, Anne Hunsaker; Barragan, Deborah I.; Hudgins, Louanne; Taylor, Joanne

doi:10.1002/pd.4599

Cited by 37 publications

(44 citation statements)

References 19 publications

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“…Special attention should be given to women with a lower educational level and/or inadequate health literacy. A study among Latina women in the US showed that women with a lower level of education more often decline NIPT based on insufficient knowledge 32. Moreover, women from ethnic minority groups less often make an informed choice about prenatal testing 33.…”

Section: Discussionmentioning

confidence: 99%

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Trial by Dutch laboratories for evaluation of non‐invasive prenatal testing. Part II—women's perspectives

et al. 2016

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ObjectiveTo evaluate preferences and decision‐making among high‐risk pregnant women offered a choice between Non‐Invasive Prenatal Testing (NIPT), invasive testing or no further testing.MethodsNationwide implementation study (TRIDENT) offering NIPT as contingent screening test for women at increased risk for fetal aneuploidy based on first‐trimester combined testing (>1:200) or medical history. A questionnaire was completed after counseling assessing knowledge, attitudes and participation following the Multidimensional Measure of Informed Choice.ResultsA total of 1091/1253 (87%) women completed the questionnaire. Of these, 1053 (96.5%) underwent NIPT, 37 (3.4%) invasive testing and 1 (0.1%) declined testing. 91.7% preferred NIPT because of test safety. Overall, 77.9% made an informed choice, 89.8% had sufficient knowledge and 90.5% had positive attitudes towards NIPT. Women with intermediate (odds ratio (OR) = 3.51[1.70–7.22], p < 0.001) or high educational level (OR = 4.36[2.22–8.54], p < 0.001) and women with adequate health literacy (OR = 2.60[1.36–4.95], p = 0.004) were more likely to make an informed choice. Informed choice was associated with less decisional conflict and less anxiety (p < 0.001). Intention to terminate the pregnancy for Down syndrome was higher among women undergoing invasive testing (86.5%) compared to those undergoing NIPT (58.4%) (p < 0.001).ConclusionsThe majority of women had sufficient knowledge and made an informed choice. Continuous attention for counseling is required, especially for low‐educated and less health‐literate women. © 2016 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, women from ethnic minority groups less often make an informed choice about prenatal testing 33. Diversifying the ways through which information is communicated might support informed decision‐making,32 for example, by providing written information in different languages33 or using visual aids.…”

Section: Discussionmentioning

confidence: 99%

Trial by Dutch laboratories for evaluation of non‐invasive prenatal testing. Part II—women's perspectives

et al. 2016

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“…In order to make an informed choice, it is essential that women understand the tests that they are being offered. As demonstrated by Farrell et al, (17) Latina women in the United States with poorer English competency (and lower levels of education, in general) had a lower uptake of NIPT and also lacked understanding that NIPT does not test for all chromosomal abnormalities. Since Singapore is ethnically diverse, it would be important to consider the provision of patient information leafl ets in multiple languages.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have also shown that interest in and uptake of NIPT is greater among women with higher levels of education. (17,46) Secondly, only 37.0% of women who participated were Chinese, and this does not match the overall Singapore population, which is 74.3% Chinese. In addition, a large proportion of the Chinese women who visited our clinic were originally from mainland China and did not have English as their fi rst language; since the questionnaire was set in English, participation would have been more challenging for these women.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is important that cultural and social factors are taken into consideration when advising women of their options for prenatal testing. (17,18) For example, a study carried out in Europe and Asia demonstrated that women from Northern Europe believed that choices for prenatal testing should refl ect parental choice. However, in Southern Europe, China and India, the majority of women felt that all women should have a prenatal test.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of preferences of women and healthcare professionals in Singapore for implementation of noninvasive prenatal testing for Down syndrome

Barrett¹,

Advani²,

Chitty³

et al. 2017

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INTRODUCTIONInvasive prenatal diagnosis (IPD) has long been used to prenatally diagnose Down syndrome (DS), but it is associated with a small risk of miscarriage. Noninvasive prenatal testing (NIPT) is a highly sensitive screening test using cell-free DNA in maternal blood for detection of DS without the risk of miscarriage, but it confers a small risk of false-positive and false-negative results. The implementation of these procedures into clinical practice requires an understanding of stakeholder preferences.METHODS A total of 69 health professionals (HPs) and 301 women took part in a discrete choice experiment (DCE) in which preferences for four prenatal test attributes -accuracy, time of results, risk of miscarriage and amount of information provided -were assessed. Conditional logit regression was used to analyse the data. Data on demographics and ranked preferences for test attributes was collected, and a direct choice question regarding NIPT, IPD or neither test was posed to participants. RESULTSThe women showed a preference for test safety, whereas HPs prioritised test accuracy above all other attributes.When offered a direct choice of NIPT, IPD or neither test, women aged 35 years and older, those with previous miscarriage or who knew a child with DS were more likely to choose NIPT. Chinese women preferred NIPT, whereas Indian women preferred IPD.CONCLUSION Our data highlights the need for patient-specifi c counselling, taking into account previous experiences and cultural factors. Since women and HPs prioritise different test attributes, it is essential that HPs recognise these differences in order to provide non-biased counselling.

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Alternative option labeling impacts decision‐making in noninvasive prenatal screening

Fisher

Birkeland

Reiser

et al. 2019

Journal of Genetic Counseling

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Noninvasive prenatal screening (NIPS) options for women and expectant couples have expanded with advances in the molecular analysis of circulating cell-free fetal DNA (cffDNA). Current NIPS options include evaluation for fetal aneuploidies, subchromosomal abnormalities, and more recently, monogenic disorders (Liu, Li, Fu, Chung, & Zhang, 2016). With the anticipated introduction of noninvasive prenatal whole genome sequencing (PWGS) into clinical practice, providers and patients may soon be navigating an even broader range of available screening options (Allen Chan et al., 2016;

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Knowledge, understanding, and uptake of noninvasive prenatal testing among Latina women

Cited by 37 publications

References 19 publications

Trial by Dutch laboratories for evaluation of non‐invasive prenatal testing. Part II—women's perspectives

Trial by Dutch laboratories for evaluation of non‐invasive prenatal testing. Part II—women's perspectives

Evaluation of preferences of women and healthcare professionals in Singapore for implementation of noninvasive prenatal testing for Down syndrome

Alternative option labeling impacts decision‐making in noninvasive prenatal screening

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