Knowledge regarding basic concepts of hereditary cancers, and the available genetic counselling and testing services: A survey of general practitioners in Johannesburg, South Africa

Wyk, Chantel Van; Wessels, Tina; Kromberg, J. G. R.; Krause, Amanda

doi:10.7196/samj.2016.v106i3.10162

Cited by 8 publications

(13 citation statements)

References 12 publications

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“…There is a real need for training GPs in the care of such patients, and most are interested in training (79.6%), which agrees with previous European (Nippert et al., ), US (Friedman, Cooper, Webb, Weinberg, & Plon, ; Friedman, Plon, Cooper, & Weinberg, ), Australian (Teng & Spigelman, ), and South African (Van Wyk, Wessels, Kromberg, & Krause, ) studies.…”

Section: Discussionsupporting

confidence: 85%

Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers: General practitioner and patient perspectives

Perre

Toledano

Corsini

et al. 2018

Molec Gen & Gen Med

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BackgroundGeneral practitioners (GPs) have an increasing role in referring patients with putative mutation in BRCA1/2 genes for genetics consultation and for long‐term follow‐up of mutation carriers.MethodsWe compared the expectations of the GPs’ role according to BRCA1/2 mutation carriers and to GPs themselves.ResultsOverall, 38% (58/152) of eligible GPs and 70% (176/252) of eligible patients were surveyed. Although 81% of GPs collected the family history, only 24% considered that they know criteria indicating genetics consultation and 39% sufficient knowledge of BRCA1/2 guidelines to answer patients’ questions. Twelve% of GPs were aware of the French national guidelines. Among unsatisfied patients, 40% felt that their GP was able to answer (moderately, sufficiently, or completely) specific questions about BRCA1/2 care as compared with 81% in satisfied patients. Only 33% of GPs reported being informed directly by the geneticist about the patients’ results. GPs’ main expectations for their role in BRCA1/2 carrier care were psychological support and informing relatives about screening (72% and 71%, respectively), which contrasts with the perceptions of patients, who mainly requested medical advice for BRCA1/2‐related care (51%).ConclusionThere is an important need for GP training and enhancing interactions between GPs and geneticists to improve the GP's role in BRCA1/2 screening and management.

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Section: Discussionsupporting

confidence: 85%

Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers: General practitioner and patient perspectives

Perre

Toledano

Corsini

et al. 2018

Molec Gen & Gen Med

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“…Valid informed consent demands that the participant makes a voluntary decision after adequately understanding relevant information concerning the study. However, interviewees observed that local investigators, RECs and the general public have limited understanding of genetics; but this is not unique to Uganda only (Ogunrin et al, 2019;Stein et al, 2019;van Wyk et al, 2016;Vos et al, 2017). Because of this, authors have proposed community engagement models that aim to optimize informed consent processes (Beaton et al, 2017;Moodley & Beyer, 2019;Tindana et al, 2017;Tindana et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Researchers’ perspectives on return of individual genetics results to research participants: a qualitative study

et al. 2021

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Genetic results are usually not returned to research participants in Uganda despite their increased demand. We report on researchers' perceptions and experiences of return of individual genetic research results. The study involved 15 in-depth interviews of investigators involved in genetics and/or genomic research. A thematic approach was used to interpret the results. The four themes that emerged from the data were the need for return of individual results including incidental findings, community engagement and the consenting process, implications and challenges to return of individual results. While researchers are willing to return clinically significant genetic results to research participants, they remain unsure of how this should be implemented. Suggestions to aid implementation of return of results included reconsenting of participants before receiving individual genetic results and increasing access to genetic counseling services. Community engagement to determine community perceptions and individual preferences for the return of results, and also prepare participants to safely receive results emerged as another way to support return of results. Researchers have a positive attitude toward the return of clinically significant genetic results to research participants. There is need to develop national guidance on genetic research and also build capacity for clinical genetics and genetic counseling.

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“…In concurrence, 65% of the 61 GPs surveyed felt that genetic counsellors, medical geneticists, or oncologists were more qualified to perform such tasks. 34 This sentiment was similarly highlighted in another study which reported 74% of the 27 GPs seeing it as others' duty to follow-up on genetic results. 86 On the contrary, only five studies found GPs to be fairly confident about their ability to determine the need for further evaluation based on family history, 53 with 74% of 271 GPs surveyed having had contact with patients with genetic disease weekly.…”

Section: Uncertainty Over Gp's Role In Genetic Testingmentioning

confidence: 87%

General practitioners’ (GPs) experience, attitudes and needs on clinical genetic services: a systematic review

et al. 2022

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ObjectiveThe proliferation and growing demands of genetic testing are anticipated to revolutionise medical practice. As gatekeepers of healthcare systems, general practitioners (GPs) are expected to play a critical role in the provision of clinical genetic services. This paper aims to review existing literature on GPs’ experience, attitudes and needs towards clinical genetic services.DesignA systematic mixed studies review of papers published between 2010 and 2022.Eligibility criteriaThe inclusion criterion was peer-reviewed articles in English and related to GPs’ experience, views and needs on any genetic testing.Information sourcesThe PubMed, PsycINFO, Cochrane, EMBASE databases were searched using Mesh terms, Boolean and wildcards combinations to identify peer-reviewed articles published from 2010 to 2022. Study quality was assessed using Mixed Methods Appraisal Tool. Only articles that fulfilled the inclusion criteria were selected. A thematic meta-synthesis was conducted on the final sample of selected articles to identify key themes.ResultsA total of 62 articles were included in the review. Uncertainty over GPs’ role in providing genetic services were attributed by the lack of confidence and time constraints and rarity of cases may further exacerbate their reluctance to shoulder an expanded role in clinical genetics. Although educational interventions were found to increasing GPs’ knowledge and confidence to carry out genetic tasks, varied interest on genetic testing and preference for a shared care model with other genetic health professionals have resulted in minimal translation to clinical adoption.ConclusionThis review highlights the need for deeper exploration of GPs’ varied experience and attitudes towards clinical genetic services to better facilitate targeted intervention in the adoption of clinical genetics.

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Knowledge regarding basic concepts of hereditary cancers, and the available genetic counselling and testing services: A survey of general practitioners in Johannesburg, South Africa

Abstract: Many of the GPs in this study had limited knowledge about inherited cancers, cancer risk management and genetic services. Appropriate education needs to be increased so that they are better equipped to identify and refer families at risk.

Cited by 8 publications

References 12 publications

Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers: General practitioner and patient perspectives

Role of the general practitioner in the care of BRCA1 and BRCA2 mutation carriers: General practitioner and patient perspectives

Researchers’ perspectives on return of individual genetics results to research participants: a qualitative study

General practitioners’ (GPs) experience, attitudes and needs on clinical genetic services: a systematic review

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