Knowledge of symptoms and diagnostic possibilities of cancer diseases

Kozłowska, Elżbieta; Szewczyk, Maria T.; Banaszkiewicz, Zbigniew; Jawień, Arkadiusz; Cierzniakowska, Katarzyna; Jarmocik, Paweł

doi:10.5114/aoms.2011.22082

Cited by 11 publications

(11 citation statements)

References 10 publications

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“…During last decades major advances have been made in screening for risk factors associated with breast cancer in high-prevalence areas [2]. Knowledge regarding clinical symptoms of breast cancer and the possibilities of screening tests among healthy population is higher comparing to the other malignancies and wide acceptance among women for breast cancer screening results in increased detection rate of early breast cancer [3]. Additionally to improve long term outcome multidisciplinary approach including surgery, chemotherapy and radiotherapy is proposed to most breast cancer patients.…”

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confidence: 99%

Expression of IAP family proteins and its clinical importance in breast cancer patients

Pluta¹,

Jeziorski²,

Cebula-Obrzut³

et al. 2015

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Inhibitor of apoptosis (IAP) family proteins is involved in mechanisms of resistance to apoptosis in various cancer cells. The aim of this study was to assess the expression of selected IAP proteins such as XIAP, cIAP-1, cIAP-2 and survivin in breast cancer patients and evaluates their relationship with the prognostic and predictive factors and their impact to overall survival (OS) and progression free survival (PFS). The study was conducted with the use of tissue samples prospectively collected from 92 previously untreated female breast cancer patients. The control encompassed 10 fibroadenoma patients. The expression of XIAP, cIAP-1, cIAP-2 and survivin was assessed using flow multicolor cytometry. XIAP expression was present in 99 % of the breast cancer patients (91/92) with the median expression 13.65% (range 1-66.8%). Expression of XIAP in breast cancer was significantly higher compared to the control group (p=0.006). Median expression of cIAP-1, cIAP-2 and survivin in the study group was 25.95% (range 0.8-83.7%), 16.7% (range 1-53.2%) and 4.6% (range 0-43%) respectively. In the rank Spearman test, strong correlations (p<0.001) were seen among the expressions of XIAP, cIAP-2 and survivin, in all combination. Additionally, week correlation between XIAP and cIAP-1 was observed (p=0.02). The median expression of XIAP and survivin was significantly higher in more advanced tumors (stages pT2/pT3 vs. pT1). The median PFS and OS in breast cancer group were 46.15 and 47.1 months respectively. No significant correlations were observed among expressions of IAP family proteins and survival. However, low expression of XIAP in breast cancer showed trend to longer PFS (p=0.08). XIAP, cIAP-1 cIAP-2 and survivin participate in antiapoptotic mechanisms in breast cancer and XIAP and survivin seem to have the most significant prognostic importance. Further studies are needed to establish more complete prognostic and predictive values of IAP family proteins in breast cancer patients.

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confidence: 99%

Expression of IAP family proteins and its clinical importance in breast cancer patients

Pluta¹,

Jeziorski²,

Cebula-Obrzut³

et al. 2015

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“…These differences were statistically significant. Even fewer people were aware of the possibilities of early detection of prostate cancer; only patients from the Urology Ward showed undeniably better knowledge of screening tests (42%) in comparison to healthy people [22]. Based on the analysis of knowledge regarding colon cancer symptoms and its screening tests, patients from the Thoracic and Cancer Surgery Ward have the least knowledge (20% and 12%) and those hospitalized in the Breast Diseases Ward and Urology Ward the most.…”

Section: Analysis Of Resultsmentioning

confidence: 99%

Assessment of knowledge in patients of surgical wards regarding clinical symptoms and diagnostics of most common malignant tumors

Kozłowska¹,

Szewczyk

2012

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Aim of the studyThe aim of this work was to evaluate the knowledge of symptoms and prophylaxis among hospitalized patients.Material and methodsThe research was carried in the Provincial Hospital in Bydgoszcz (i.e. general surgery, gynecology and obstetrics, urology, breast surgery and thoracic surgery). 250 hospitalized patients took part in the tests, as well as 50 healthy people. The scientific method used was a specially designed questionnaire. The Bioethics Committee of Collegium Medicum of Mikołaj Kopernik University in Bydgoszcz approved these tests.ResultsPatients from the Breast Diseases Ward had better knowledge about cancers than the control group. Symptoms of lung cancer were known to both groups to the same extent. Patients from the Clinical Ward of Thoracic Surgery were very knowledgeable about lung cancer, but they did not know anything about other malignant types of cancer. Patients from Gynecology and Obstetrics wards are better than the control group only at knowledge about symptoms and screening of cervix cancer. Patients from the Urology Ward have the best knowledge about screening of prostate cancer and colon cancer. Those hospitalized at the Surgery Ward do not know symptoms of colon cancer, but they have knowledge about its screening.Conclusions Patients from the Clinical Ward of Thoracic and Cancer Surgery and the Clinical Surgery Ward had the least knowledge about malignant tumors.Patients from Urology, Gynecology and Obstetrics wards have better knowledge about malignant tumors treated there.

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“…However, in more than 70% of cases the surgical approach is contraindicated due to poor liver reserve, insufficient health status, or an overly advanced tumor stage [18,24–28]. For this reason, there is a need for alternative treatment options for patients with unresectable liver malignancies [29–31].…”

Section: Discussionmentioning

confidence: 99%

Thermal ablation of unresectable liver tumors: Factors associated with partial ablation and the impact on long-term survival

et al. 2012

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SummaryBackgroundThermal ablation procedures, including radiofrequency ablation (RFA) or laser-induced interstitial thermotherapy (LITT), are now well established in the treatment of malignant unresectable hepatic tumors. But the impact of partial ablation (PA) on long-term survival following computed tomography (CT)-guided radiofrequency ablation and laser- induced interstitial thermotherapy of unresectable malignant liver lesions and the associated risk factors of PA remain partially unknown.Material/MethodsThis study included 254 liver tumors in 91 consecutive patients (66 men and 25 women; age 60.9±10.4 years; mean tumor size 25±14 mm [range 5–70 mm]) who underwent thermal ablation (RFA or LITT) between January 2000 and December 2007. Mean follow-up period was 21.1 month (range 1–69 months). Survival rate and local progression-free survival (PFS) were calculated for patients with complete ablation (CA) vs. patients with partial ablation (PA) to assess the impact on long-term survival.ResultsMedian survival after CA was 47 months compared to 25 months after PA (P=0.04). The corresponding 5-year survival rates were 44% vs. 20%. Median PFS for CA was 11 months compared to 7 months for PA (P=0.118). The sole statistically significant risk factor for PA was tumor size (>30 mm; P=0.0003). Sustained complete ablation was achieved in 71% of lesions ≤30 mm vs. 47% of lesions >30 mm.ConclusionsWe conclude that achievement of complete ablation is a highly important predictor of long-term survival and that tumor size is by far the most important predictor of the likelihood of achieving complete ablation.

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Knowledge of symptoms and diagnostic possibilities of cancer diseases

Cited by 11 publications

References 10 publications

Expression of IAP family proteins and its clinical importance in breast cancer patients

Expression of IAP family proteins and its clinical importance in breast cancer patients

Assessment of knowledge in patients of surgical wards regarding clinical symptoms and diagnostics of most common malignant tumors

Thermal ablation of unresectable liver tumors: Factors associated with partial ablation and the impact on long-term survival

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