Knowledge of supplemental folic acid during pregnancy

Tavares, Beatriz Barco; Sabino, Ana Maria Neves Finochio; Lima, Juliana Cristina; Garcia, Claudia Tozzo

doi:10.17533/udea.iee.v33n3a09

Cited by 7 publications

(7 citation statements)

References 10 publications

(16 reference statements)

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“…In our study, lemongrass infusion was not able to reverse protein damage, except in the 3 th gestational phase, where a small reduction in CP levels can be observed, supporting the previous hypothesis that the lipids are molecules more susceptible to the action of free radicals and also, of the antioxidants, like the GSH 29,38 . On the other hand, the protein carbonylation process is irreversible 30 , because there are proteolytic systems that eliminate damaged proteins and recycle amino acids with the purpose of performing protein synthesis.…”

Section: Use Of Vitamin Complexes During the Gestational Periodsupporting

confidence: 90%

“…Reinforcing the presence of the antioxidant compounds in the lemongrass infusion, it showed good ability to eliminate free radicals. A study with C. citratus leaves that also detected the presence of flavonoids, tannins and phenolic compounds in the plant verified that the tannins and flavonoids fractions were the main responsible for the antioxidant activity found in the lemongrass infusion 38 .…”

Section: Use Of Vitamin Complexes During the Gestational Periodmentioning

confidence: 87%

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Redox Alterations in Pregnant Women: Antioxidant Effect of Lemongrass (Cymbopogon Citratus (Dc.) Stapf) Alterações Redox Em Gestantes: Efeito Antioxidante Do Capim-Limão (Cymbopogon Citratus (Dc.) Stapf)

Rubin

Horn²,

Hirsch

et al. 2020

BJD

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Section: Use Of Vitamin Complexes During the Gestational Periodsupporting

confidence: 90%

Section: Use Of Vitamin Complexes During the Gestational Periodmentioning

confidence: 87%

Redox Alterations in Pregnant Women: Antioxidant Effect of Lemongrass (Cymbopogon Citratus (Dc.) Stapf) Alterações Redox Em Gestantes: Efeito Antioxidante Do Capim-Limão (Cymbopogon Citratus (Dc.) Stapf)

Rubin

Horn²,

Hirsch

et al. 2020

BJD

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“…Dentre os micronutrientes necessários nessa fase, é preciso atenção especial ao suprimento de ferro e ácido fólico (Freitas, Bosco, Sipped, & Lazzaretti, 2010;Tavares, Sabino, Lima, & Garcia, 2015).…”

Section: Introductionunclassified

Suplementação individualizada de ferro e ácido fólico para gestantes adultas

Torres

Salvador

Batista

et al. 2020

RSD

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Objetivos: verificar a adequação da ingestão de ferro e ácido fólico por gestantes de acordo com as recomendações preconizadas para essa fase. Métodos: Estudo transversal que envolveu 24 gestantes atendidas em Unidades Básicas de Saúde. As gestantes responderam ao questionário com dados socioeconômicos e gestacionais conforme dados presentes na caderneta da gestante do Ministério da Saúde. O estado nutricional das gestantes foi classificado conforme o Índice de Massa Corporal gestacional. A quantificação da ingestão dietética referente à energia, macronutrientes, ferro e ácido fólico foram calculadas com o auxílio do programa NutWin. Para fins de adequação, os resultados foram comparados com os valores de referência recomendados pela Organização Mundial de Saúde para energia e marcronutrientes e com o proposto pelo Institute of Medicine para micronutrientes durante o período gestacional. Resultados: Com relação ao estado nutricional, 41,7% estavam com o peso adequado, 25% com sobrepeso e 16,7% com obesidade. Observou-se diferença estatisticamente significativa entre a ingestão e recomendação de carboidratos (p < 0,05), ácido fólico alimentar (p < 0,05), ácido fólico total (p < 0,05), ferro alimentar (p < 0,05) e ferro total (p < 0,05). Das 24 gestantes 58,3% eram casadas, 83,3% completaram ensino médio ou superior e 100% tinham a renda mensal menor que 5 salarios mínimos. Conclusão: As gestantes apresentam inadequação quanto ao consumo de micronutrientes, o que evidencia a importância da suplementação individualizada das mesmas, com base na análise prévia da ingestão alimentar de micronutrientes e biomarcadores dos mesmos, para melhor atender as necessidades individuais desse período.

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“…Folate deficiency is associated with megaloblastic anemia, neural tube defects, cardiovascular diseases, irritability, diarrhea, and psychiatric disorders [3–7]. In pregnant women, it may result in neural tube defects, developmental retardation, and early spontaneous abortion [8, 9]. Therefore, in vitro diagnostic of FA is particularly important.…”

Section: Introductionmentioning

confidence: 99%

Development of a Sensitive Chemiluminescence Immunoassay for the Quantification of Folic Acid in Human Serum

Chen

Zhou²,

Zhang

et al. 2019

Journal of Analytical Methods in Chemistry

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Folic acid (FA) is an important vitamin for human growth, especially for pregnant women. FA deficiency is associated with megaloblastic anemia, neural tube defects, cardiovascular diseases, irritability, diarrhea, and psychiatric disorders. Normally, FA molecules bind to folate-binding protein (FBP) in the serum as complex. Before quantify the FA concentration, a releasing procedure should be conducted. Alkaline condition and tris(2-carboxyethyl)phosphine (TCEP) are used to release binding FA to freeing state. In this work, a chemiluminescence immunoassay (CLIA) for human serum FA was established by competition model. Streptavidin (SA) was labeled to magnetic beads by an 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDAC/NHS) method. Activated biotin molecules were labeled to FBP molecules purified from milk. FA was labeled to horseradish peroxidase (HRP) by EDAC to activate the FA molecules. The pretreated samples or standards were added into the reaction tube with biotin-FBP and FA-horseradish peroxidase (HRP), FA in the sample compete with FA-HRP for binding to biotin-FBP, the signal is inversely proportional to the FA concentration. The method established shows good thermostability and performance. The limitation of detection (LOD) is 0.44 ng/mL. The intra-assay coefficient of variation (CV) is 3.6%–7.1%, the interassay CV is 4.2%–7.5%, and the recovery rate is 92.1%–103.5%. Cross reactivity (CR) was remarkably low with aminopterin, folinic acid, and methotrexate. The method shows good correlation with the FA CLIA product from Beckman Coulter; the equation is y = 0.9618x−0.1434 while the R2 value is 0.9224. The established method is sensitive, rapid, and accurate which can fully satisfy for the clinical requirement.

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Knowledge of supplemental folic acid during pregnancy

Cited by 7 publications

References 10 publications

Redox Alterations in Pregnant Women: Antioxidant Effect of Lemongrass (Cymbopogon Citratus (Dc.) Stapf) Alterações Redox Em Gestantes: Efeito Antioxidante Do Capim-Limão (Cymbopogon Citratus (Dc.) Stapf)

Redox Alterations in Pregnant Women: Antioxidant Effect of Lemongrass (Cymbopogon Citratus (Dc.) Stapf) Alterações Redox Em Gestantes: Efeito Antioxidante Do Capim-Limão (Cymbopogon Citratus (Dc.) Stapf)

Suplementação individualizada de ferro e ácido fólico para gestantes adultas

Development of a Sensitive Chemiluminescence Immunoassay for the Quantification of Folic Acid in Human Serum

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