Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021

Abstract

BackgroundRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC is asymptomatic, many patients present metastatic diseases at first diagnosis. With the development of immunotherapy, the treatment of RCC has entered a new stage and has made a series of progress. This study mainly outlines the knowledge map and detects the potential research hotspots by using bibliometric analysis.MethodsPublications concerning RCC immunotherapy from 2002 to 2021 in the Web of Science Core Collection were collected. Visualization and statistical analysis were mainly performed by freeware tools VOSviewer, CiteSpace, R software, and Microsoft Office Excel 2019.ResultsA total of 3,432 papers were collected in this study, and the annual number of papers and citations showed a steady growth trend. The United States is the leading country with the most high-quality publications and is also the country with the most international cooperation. The University of Texas MD Anderson Cancer Center is the most productive organization. The Journal of Clinical Oncology is the highest co-cited journal, and Brian I. Rini is both the most prolific author and the author with the largest centrality. The current research hotspots may be focused on “immune checkpoint inhibitors (ICIs),” “PD-1,” and “mammalian target of rapamycin.”ConclusionImmunotherapy has a bright future in the field of RCC treatment, among which ICIs are one of the most important research hotspots. The main future research directions of ICI-based immunotherapy may focus on combination therapy, ICI monotherapy, and the development of new predictive biomarkers.

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

“…Bibliometrics is a branch of library and information science that integrates mathematical and statistical methods to quantitatively analyze the published scientific literature, and then discusses its structure, characteristics and change trends in a certain period ( Cheng et al, 2022a ; Li et al, 2022a ; Shen et al, 2022a ; Cheng et al, 2022b ). In recent years, with more and more free open-source software such as CitNetExplorer, CiteSpace, HistCite, VOSviewer, and Bibliometrix have been developed, bibliometrics relying on literature databases has been frequently applied in biomedical field ( Synnestvedt et al, 2005 ; van Eck and Waltman, 2010 ; Aria and Cuccurullo, 2017 ; Liu et al, 2022 ). Take ultrasound technology as an example, several bibliometric studies have analyzed the publication trend and research hotspots in the field of spinal ultrasound ( Zhai et al, 2017 ), endoscopic ultrasound ( Chen et al, 2022 ), ultrasound microbubble ( Wu et al, 2021a ), ultrasound induced blood-brain barrier opening ( Wu et al, 2021b ).…”

Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study

“…Journal analysis is able to assist researchers accurately grasp the core journals in their research fields and quickly find the suitable journals for literature queries, data collection, and manuscript submission ( 29 , 40 , 41 ). Therefore, we have summarized the detailed information of the top 20 active journals in this field.…”

Bibliometric evaluation of 2020–2022 publications on COVID-19-related cardiovascular disease

“…From the analysis result of the R Bibliometrix package, we easily obtained information from annual publications, which was then exported to Excel as data to forecast outputs of the next few years. Additionally, outputs of authors, countries/regions, and journals were obtained from this module (23,24). Moreover, information about total and annual publications, total cited articles, and total times were acquired.…”