Knowledge mapping and current trends of global research on CRISPR in the field of cancer

Abstract

Background: Gene editing tools using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-related systems have revolutionized our understanding of cancer. The purpose of this study was to determine the distribution, collaboration, and direction of cancer research using CRISPR.Methods: Data from the Web of Science (WoS) Core Collection database were collected from 4,408 cancer publications related to CRISPR from 1 January 2013to 31 December 2022. The obtained data were analyzed using VOSviewer software for citation, co-citation, co-authorship, and co-occurrence analysis.Results: The number of annual publications has grown steadily over the past decade worldwide. The United States was shown, by far, to be the leading source of cancer publications, citations, and collaborations involving CRISPR than any other country, followed by China. Li Wei (Jilin University, China), and Harvard Medical School (Boston, MA, United States) were the author and institution with the most publications and active collaborations, respectively. The journal with the most contributions was Nature Communications (n = 147) and the journal with the most citations was Nature (n = 12,111). The research direction of oncogenic molecules, mechanisms, and cancer-related gene editing was indicated based on keyword analysis.Conclusion: The current study has provided a comprehensive overview of cancer research highlights and future trends of CRISPR, combined with a review of CRISPR applications in cancer to summarize and predict research directions and provide guidance to researchers.

Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study

“…Liu et al. [ 47 ] described the trends and status in CRISPR-related cancer therapy field from 2013 to 2022, and pointed out research directions of cancer-related gene editing, mechanisms, and oncogenic molecules. A bibliometric study on mesenchymal stem cell-derived EVs was conducted by Zhang et al.…”

Advances in Environmental Biotechnology with CRISPR/Cas9: Bibliometric Review and Cutting-Edge Applications

“…They peaked in 2022, rising from 1603 to 3125 citations, suggesting that research on CRISPR/Cas9 applications in Environmental Biotechnology has accelerated steadily. This sustained increase in citations from 2020 may suggest a growing recognition and acceptance of CRISPR/Cas9 applications in Environmental Biotechnology [126]. The peak in 2022 could indicate that technological advances, significant discoveries, or an increasing awareness of the possibilities of CRISPR/Cas9 may have contributed to this positive trend [127][128][129], indicating a promising period for future research in this area.…”