“…Many are focused on specific application domains such as metabolic engineering (Helmy et al, 2020 ), precision medicine (Hamamoto et al, 2019 ), amongst others (e.g., Mann et al, 2021 ; Lin et al, 2022 ; Zhou et al, 2022 ) and a majority focused on cancer research (e.g., Wang and Gu, 2016 ; Biswas and Chakrabarti, 2020 ; Nicora et al, 2020 ; Cai et al, 2022 ). Finally, a handful of reviews are dedicated to discussion of subsets of general AI and ML approaches to multi-omics data integration (e.g., Li et al, 2016 ; Huang et al, 2017 ; Kim and Tagkopoulos, 2018 ; Picard et al, 2021 ; Reel et al, 2021 ; Lee and Kim, 2022 ) with some attention given to limitations of methods, such as interpretability of models.…”