Knowledge exchange, defined as interpersonal interactions that change knowledge in the heads and/or knowledge in the world, is a topic of interest in many research fields. This chapter outlines a conceptual framework which captures many variables that play a role in knowledge exchange. The conceptual framework draws a distinction between input variables, process variables, and output variables. Moreover, the framework stresses the importance of taking both individual-level variables and group-level variables into account in order to describe and explain knowledge exchange. These variables can be used to describe and categorize a broad range of empirical studies from various scholarly fields. Patterns of covariation that are discovered in the network of variables have the potential to transform the conceptual framework of knowledge exchange into a theoretical framework.