Pakistan has faced a chain of epidemics over the last two decades. However, Pakistan is included among low-ranked healthcare countries yet has tackled this worldwide disease nicely. The purpose of the current study is to check the residents' awareness level and preventive practices about dengue disease and further find out the factors affecting knowledge, attitudes, and practices. The quantitative approach was used to conduct the study, and the target population was residents of peri-urban and rural areas of the Multan district. A sample of 200 residents was selected using the multi-stage cluster sampling technique. The researcher got significant and valuable results. It is seen that citizens of peri-urban are more conscious about preventive practices; moreover, the research depicts that as the quality of education improves, awareness and attitudes also improve. Based on the findings, the researcher has given valuable suggestions to the policymakers and future researchers that would help in policy making.