Abstract:Background: Frontoethmoidal encephalomeningocele (FEEM) is a neural tube defect (NTD) characterized by a persistent foramen cecum and herniation of cranial contents through an anterior skull defect. The mycotoxin fumonisin, a contaminant of maize, has been implicated in the pathogenesis of FEEM as it disrupts sphingolipid metabolism and decreases folate bioavailability. Studies have demonstrated that exposure to fumonisin in experimental animals induces FEEM. A high prevalence of FEEM has been observed at the … Show more
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