a pretest-posttest questionnaire. Findings and Implications The educational intervention significantly increased the providers' and staff knowledge about hepatitis C. There was an average gain of 16.76 points (95% confidence interval, 13.32, 20.20) on a knowledge test after the educational presentation. This gain was statistically significant at p ≤ .05 by the paired t-test (two-tailed). Improvements were seen for Havrix (16.9% pre-intervention, 19.7% post-intervention); Engerix-B (2.3% preintervention, 3.5% post-intervention); and Twinrix (20.8% pre-intervention, 21.4% postintervention). Overall vaccination rates were increased by 4.6% in a predominantly publicly insured patient population. The goal of increasing vaccination rates by 20% was not met. However, multi-strategy, evidence-based interventions were an effective means of increasing HAV and HBV vaccinations in a community health center and led to increased access to vaccination services, increased community demand for vaccines, and improved system-based performance.