Background: Ethiopia has taken unprecedented preventive measures like closure of higher education institutions to halt the spread of COVID-19. However, still, there is scarce information regarding the knowledge, attitude, and practice (KAP) of students towards COVID-19 pandemic. Thus, this study aimed to assess the KAP and associated factors of preventive measures against COVID 19 among students.Methods: A cross-sectional study design was conducted among 422 students. The sample was proportionally allocated into the randomly selected four colleges and the students were recruited using a systematic random sampling technique. Variables with p-value < 0.25 in the bivariate logistic regression analysis were entered into the multivariable logistic regression model.Results: this study involved 408 students with response rate of 96.6%. The level of good knowledge, positive attitude and good practice were 69.6%, 56.6% and 65% respectively. After adjusting for covariates; being in the late adolescent age group (16-20), living with > 5 family size, and being single were predictors of knowledge level. Besides, being single, learning Diploma (TVET) level trainings, and being year-two students were predictors of attitude levels. Similarly, urban residence, being regular students, and being year-one students were the independent predictors of practice level of students.Conclusions: The national and local governments should develop effective and inclusive prevention strategies to address students who are at home due to COVID-19 pandemic.