Background: With a mortality rate of nearly 5.5 million annually, stroke is classified as the second leading cause of death worldwide. A high mortality rate is not only the burden of stroke but also leads to permanent disability to 50% of the survivors, so stroke is a spacious disease on public health with severe social and economic outcomes. A survey conducted about the 10 causes of death in Saudi Arabia in 2017, the mortality rate due to stroke was 6.4%. Aim: To assess the knowledge level of high school students about stroke. Methods: A cross sectional research design was utilized to collect the data from students of one of high schools in Al Ahsa, Eastern Region, Saudi Arabia. A convenient sampling method was used to select the study sample. The researchers distributed 120 questionnaires and collected 101 complete questionnaires, which gave a response rate of (84.2%). A self-structured questionnaire survey was conducted between high school students regarding stroke knowledge. Results: The total score of knowledge about stroke ranged from 3-11 out of 17 (Mean 7.04 + 2.5). However, most of the subjects have a low-degree knowledge score (91.1%). Conclusion: There was inadequate awareness of stroke among students, in spite of the fact that it corresponds to a major number of deaths worldwide.