Knowledge and practices about safe handling regarding the risk of exposure to antineoplastic drugs for caregivers in compounding units and in operating rooms performing HIPEC/PIPAC

Abstract

Introduction Ever since the late 1970s, occupational exposure associated with the handling of antineoplastic drugs (ADs) in the healthcare environment has been highlighted and demonstrated. Contamination was detected in both operating rooms (OR) and compounding units (CU), where healthcare workers handle and are exposed to ADs in different ways. In the OR, the risk of exposure is higher and the staff receives less training in handling ADs than in the CU. This study aimed to assess and compare knowledge and practices about the safe handling of ADs by caregivers working in these two locations, namely the CU and OR. Methods Two questionnaires (one each for the OR and CU) were created by two investigator pharmacists and were completed during a personal interview of 20 min. The questions were related to the following topics: training, knowledge about occupational exposure and questions related to protective practices. A scoring system was implemented to assess the knowledge and practices of each participant. Results In total, 38 caregivers working in the OR and 39 in the CU were included in our study. Significantly more CU staff had specific initial training ( p < 0.001) and ongoing training ( p < 0.001) in handling ADs. Concerning the knowledge score, OR caregivers had a significantly lower median score for contamination routes ( p < 0.001), contamination surfaces ( p < 0.001), existing procedures ( p < 0.001) and total knowledge ( p < 0.001) than CU caregivers. Concerning protective handling practices of ADs, the two locations had nonsignificantly different median scores ( p = 0.892). Conclusion This study suggests that there is still room for improvement in terms of knowledge and protection practices when handling ADs. An appropriate and tailored training program should be developed and provided to all caregivers who handle or come in contact with ADs. Clinical trial registration Study CONTACT, ref. 19-504.

Impact of lack of knowledge on risk perception and protective practices of home nurses handling antineoplastic drugs

“…9 The assessment of blood contamination by ADs and the impact of the lack of knowledge on risk perception and protective practices related to the handling of ADs of hospital caregivers within risk areas of exposure such as compounding units, oncology day hospitalization units and operating rooms showed a significant level of blood contamination by ADs and disparities in knowledge and handling practices of ADs. [10][11][12][13][14] However, the patient's home with the development of ambulatory medicine is also becoming a risk area of exposure that has been poorly evaluated until now.…”

“…15 In addition to studies on biological and environmental contamination, studies have also been conducted on health care workers' knowledge, perception, and protective practices when handling ADs. 12,14,16,17 Hon and Abusitta revealed the existence of immediate and contributing causes, including the lack of training, which can lead to risky practices. 18 The aim of this study was to assess the impact of the lack of knowledge on risk perception and on protective practices related to the handling of HC by home nurses.…”