Climate change's intensifying impact on human health necessitates effective advocacy and communication strategies. In this review that spans research in multiple languages published from 2000 to 2023, we summarize evidence on effective advocacy and communication strategies at the intersection of climate change and health for public audiences, health professionals, and public officials. First, we synthesize research on public audiences, including their perceptions of climate change and health, public responses to health-framed climate information, climate and health risks and solutions, information about vulnerable populations and equity considerations, climate- and health-related visual communication and imagery, and their perceptions of health professionals. Then, we provide an overview of research on health professional audiences, including their role in climate and health communication and advocacy, knowledge of the connections between climate and health, willingness to engage with the topic and in climate-relevant actions, and ways to encourage this engagement. Next, we delve into public officials’ perspectives and comprehension of the relationship between climate change and health. Lastly, we end with recommendations for a research agenda to fill the gaps illuminated in this review and foster a growing field on climate and health insight and engagement.