Knowledge and attitudes regarding genetic testing among Jordanians: An approach towards genomic medicine

Khdair, Sawsan I.; Al‐Qerem, Walid; Jarrar, Wassan

doi:10.1016/j.sjbs.2021.04.004

Cited by 13 publications

(40 citation statements)

References 35 publications

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“…Other reasons for partaking in genomic testing suggested by Qatari adults included improved health knowledge and prevention of future health conditions [46]. This was also suggested by participants in Etchegary et al [51], Hahn et al [53] Khadir, Al-Qerem and Jarrar [56].…”

Section: Domain 4: Adopter Systemmentioning

confidence: 97%

“…Lee et al [57] found that older adults were more likely to approve of integrating personalised medicine testing into standard healthcare. Two other studies also found that older adults were slightly more interested in genomic testing [54,56]. In contrast, Okita et al [59] found that older adults were less willing to partake in genomic testing, while Dodson et al [49] found no association between age and likeliness to have testing.…”

Section: Demographic Characteristicsmentioning

confidence: 97%

“…Sixteen studies were included in the analysis [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61]. Most were quantitative (n = 12), using questionnaires to assess public perceptions [46-52, 54, 56, 57, 59, 61].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Education level influenced decisions to hypothetically partake in genomic testing in different ways [49,51,56,59,61]. Three studies found that more educated individuals were more likely to be interested in testing [49,56,59], while two other studies found that being more educated led to more critical attitudes towards testing [51,61]. One study found no association between education level and attitude towards testing [57].…”

Section: Demographic Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

How does the genomic naive public perceive whole genomic testing for health purposes? A scoping review

2022

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The benefits of genomic testing are primarily reported in rare disease, cancer diagnosis and disease management. However, as research into its application in common, more complex conditions grows, as well as the increased prevalence of carrier screening programs, the genomic naive public is more likely to be offered testing in future. To promote social acceptability and ethical application of this technology, it is essential that public perceptions of genomics are considered. Previous studies, however, have primarily focussed on the views of those with genetic conditions or those undergoing genetic testing. The aim of this scoping review is to investigate the genomic naive public’s perceptions of clinical genomics and clinical genomic testing. Embase, MEDLINE and PubMed databases were searched, with a total of 3460 articles identified. Data analysis was organised according to the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework. Sixteen full-text articles were included in the final analysis. Most of the studies used questionnaires to determine attitudes of the public toward clinical genomics (n = 12). Public perceptions were found to underpin technology (Domain 2), value proposition (Domain 3), the adopter system (Domain 4) and the wider context (Domain 6) of the NASSS framework, highlighting its importance when considering implementation of an innovative technology such as genomic testing. Our study shows public perceptions are diverse, and highlights the need for more studies on the views of underrepresented groups and the impact of cultural contexts on perceptions.

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Section: Domain 4: Adopter Systemmentioning

confidence: 97%

Section: Demographic Characteristicsmentioning

confidence: 97%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Demographic Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

How does the genomic naive public perceive whole genomic testing for health purposes? A scoping review

2022

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“…Understanding patients’ knowledge, attitudes, and beliefs toward genetic testing can shape pre‐ and post‐genetic testing counseling discussions and may inform if and how patients plan to utilize genetic test results. Existing research on knowledge and attitudes toward genetic testing has shown that older individuals and those with fewer years of formal education generally have more concerns about genetic testing (Calsbeek et al., 2007; Henneman et al., 2013; Khdair et al., 2021). Typical concerns included privacy and potential discrimination (e.g., insurance or healthcare) based on the genetic test results.…”

Section: Introductionmentioning

confidence: 99%

Cardiology clinic patient attitudes toward and potential personal utility of genetic testing: Findings from a unique multiracial clinical sample

Erickson

Clark

Umucu

et al. 2022

Journal of Genetic Counseling

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As more is understood about the hereditary nature of disease risk, the utility of genetic testing within cardiovascular medicine is increasingly being explored. Although testing may afford more personalized risk stratification, there is a paucity of information regarding patient knowledge, attitudes, and beliefs toward genetic testing among cardiology patients. Participants (n = 530) recruited primarily from a cardiology clinic filled out a 41‐item written questionnaire assessing knowledge, beliefs, and attitudes toward genetic testing, motivators and detractors for considering genetic testing, and perceived likelihood for behavior change after hypothetical genetic testing risk stratification. Path analysis was used to test the hypothetical models predicting the likelihood of getting a genetic test and making behavior changes following genetic testing. The patient population was late‐middle‐aged (59.0 ± 14.5 years), majority women (61.5%), and about half reported having a bachelor's degree. 58.1% of participants self‐identified as White, 25.7% as African American or Black, 6.8% as Spanish, Latino, or Hispanic, 3.0% as Asian or Pacific Islander, and 0.5% as Native American. Gender (being a woman) and more years of education were related to greater knowledge about genetic testing. Racial identity and years of education were related to beliefs about genetic testing. Beliefs, but not knowledge, were related to more positive attitudes and a higher likelihood of pursuing genetic testing. Positive attitudes were related to greater perceived personal control (PPC). Furthermore, attitudes and PPC were related to higher likelihood of lifestyle change after genetic testing. These results highlight the need to integrate the experiences of racialized communities into education/counseling efforts. Most educational counseling efforts lack a nuanced discussion of social determinants of health or beliefs. In addition to factual information, educational counseling must also address people's beliefs, concerns, and the intersecting experiences and identities, which shape patients' relationships with the evolving landscape of healthcare and personalized medicine.

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Informed consent for expanded carrier screening: Past, present, and future

Rink

2023

Prenatal Diagnosis

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History, law, bioethics, and geocultural influences all have impacted the modern application of informed consent. It is a complex, multilayered process to communicate information and obtain voluntary patient permission before a health care intervention. Lack of provider education about genetic disorders, complexities of advanced genomic technologies, limited time during patient encounters, and low health literacy within a population all represent challenges to effective communication. There is no consensus on how informed consent in reproductive genetics is optimally obtained. Expanded carrier screening (ECS) is purposed to simultaneously test for a large list of diseases in a pan‐ethnic manner. The increased use of ECS is driven by advances in genomic technologies, decreased cost, an improved understanding of single gene disorders, and in support of reproductive autonomy. Academic organizations recommend pretest counseling when patients consider ECS, yet best practice is not established. Ongoing research is needed to determine how optimally implement informed consent given the increased complexity of ECS.

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Knowledge and attitudes regarding genetic testing among Jordanians: An approach towards genomic medicine

Cited by 13 publications

References 35 publications

How does the genomic naive public perceive whole genomic testing for health purposes? A scoping review

How does the genomic naive public perceive whole genomic testing for health purposes? A scoping review

Cardiology clinic patient attitudes toward and potential personal utility of genetic testing: Findings from a unique multiracial clinical sample

Informed consent for expanded carrier screening: Past, present, and future

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