The authors developed the Nurse-Led Educational Program (NLEP) about HPV infection, HPV vaccination, and cervical cancer. They evaluated its efficacy by using descriptive and inferential statistics. The research plan was a quantitative research study that included one group, pre-and post-test. The cluster sampling technique was employed to select the sample. The data was gathered through the structured closed-ended interview. A greater or less similar set of information about demographics was observed in both the experimental and control group. In the experimental group, the significance of differences between pre-tests and post-test was tested statistically by using a paired test and found to be extremely relevant and there was no correlation between pre-test knowledge scores and post-test knowledge score demographic variables. The results of the study showed that there was a substantial improvement in the knowledge level of rural women about HPV infections, HPV vaccination, and cervical cancer. This means that NLEP is highly effective in rural women.