Knowledge and associated factors towards cytotoxic drug handling among University of Gondar Comprehensive Specialized Hospital health professionals, institutional-based cross-sectional study

Simegn, Wudneh; Dagnew, Baye

doi:10.1186/s12199-020-00850-z

Cited by 11 publications

(10 citation statements)

References 28 publications

(36 reference statements)

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“…This study discovered that there is no statistically significant difference between the knowledge of nurses about chemotherapy management and their age at a p-value > 0.05. This result goes along with the one of the previous studies that found no statistically significant correlation between knowledge of nurses and their ages (36) . Also, in a cross-sectional study in Jordan carried out by al qadire and alkhalaileh, they mentioned in their study that there is no connection between nurses' knowledge and age (37) .…”

Section: Discussionsupporting

confidence: 90%

Nurse’s knowledge toward oncology patients during chemotherapy management

Watheeq¹,

AI-Ashour²

2022

ijhs

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Cancer is an international health problem with a growing occurrence. Chemotherapy is currently the standard of care for the majority of solid tumors and hematologic malignancies. Oncology nurses play a significant role in care delivery and patient education. Objective(s): This study aims at assessing the knowledge of nurses toward oncologic patients during chemotherapy management. In addition, to find out the relationship between nurses’ knowledge and their demographic variables. Methodology: A descriptive cross-sectional quantitative study has been conducted for the period between the 1st of November 2021 and 1st of June 2022. A non-probability sampling technique (total purposive sampling method) is conducted on (47) nurses. A self-administrated questionnaire have been used for data collection in the current study, which has included two parts; the first part deals with the nurse’s demographic information, and the second part includes the nurse’s knowledge about the chemotherapy management. Results: The majority of nurses have a pass level of knowledge with a Significant association found between the knowledge of nurses and (level of education and training section). Conclusions: The study concluded that the nurses with higher education degrees are the ones who have the most essential knowledge of chemotherapy management.

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Section: Discussionsupporting

confidence: 90%

Nurse’s knowledge toward oncology patients during chemotherapy management

Watheeq¹,

AI-Ashour²

2022

ijhs

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“…Although the literature on safe handling practices in LMICs is still scarce, several studies have reported unsafe practices and the need for improvements. 14 , 18 , 19 , 33 , 34 Our study's findings confirmed that the level of safe practices in some institutions remained very low. Thus, implementing safety standards and continuous quality improvement approaches in this area is of utmost importance as the number of cancer treatments will continue increasing in the coming years.…”

Section: Discussionsupporting

confidence: 78%

Development and Proof of Concept of an Audit Toolkit for the Safe Handling of Cytotoxic Drugs in Low- and Middle-Income Countries

Grünigen

Falaschi

Guichard

et al. 2021

JCO Global Oncology

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PURPOSE Chemotherapies are considered high-risk drugs for patient and staff safety. Considering the rising burden of cancer and the increasing use of chemotherapy drugs in low- and middle-income countries (LMICs), promoting continuous improvements in the safety and quality of practices in these settings is essential. This paper describes the development and proof of concept of a toolkit to audit chemotherapy handling practices in the health care facilities of LMICs. METHODS A steering committee defined the audit method and the toolkit content. Several checklists were developed to facilitate the audit and data collection. Items included in checklists were derived from key reference works on safe handling. Different tools were validated using Delphi surveys and expert reviews. Audits of pilot sites were performed to test the toolkit's applicability and relevance. RESULTS The toolkit contains a 134-item global assessment tool for the different processes at each step of the medication pathway and three step-specific observation checklists to assess different health workers' practices during the prescription, preparation, and administration of chemotherapies. The toolkit also proposes using a surface-wipe sampling method to measure any cytotoxic contamination of the immediate environment. The toolkit was tested in three teaching hospitals in Africa. CONCLUSION The toolkit developed was successfully implemented in a variety of LMIC settings, providing a comprehensive evaluation of the quality and safety of the chemotherapy drug handling practices in participating health care facilities. This toolkit can help facilities in LMICs to implement a new approach to continuously improving the quality and safety of their practices and ultimately ensure patient and staff safety.

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“…However, several studies conducted locally in resource-poor settings have previously shown unsatisfactory levels of knowledge and unsafe practices regarding the preparation and use of chemotherapy drugs. [30][31][32][33] In particular, weaknesses were revealed during the preparation and administration of chemotherapy. Although the present survey did not examine the reasons or challenges behind inappropriate practices, other studies have identified insufficient knowledge, unsuitable infrastructure, the unavailability of materials, multitasking, work pressures, and high patient loads as barriers to safety.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

The safe handling of chemotherapy drugs in low- and middle-income countries: An overview of practices

Grünigen

Geissbühler

Bonnabry

2021

J Oncol Pharm Pract

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Introduction The rising burden of cancer in low- and middle-income countries (LMICs) has led to substantial efforts to improve access to chemotherapy. The present study’s objectives were to obtain an overview of the safe handling practices implemented in LMICs’ healthcare facilities when dealing with chemotherapy drugs and to prioritize opportunities for improving them. Methods We conducted an online survey, from June 2018 to April 2019, among LMIC healthcare facilities dealing with chemotherapy drugs. Facilities were asked to self-assess their chemotherapy handling processes using Cyto-SAT, a self-assessment tool incorporating 134 items organized into 10 domains (management, personnel, logistics, prescription, preparation, administration, incident management, waste management, cleaning, and patient counselling). Data were recorded on an online platform ( www.datapharma.ch/cyto-SAT ). Results The survey enrolled 53 healthcare facilities (15 from low-income, 26 from lower-middle-income, and 12 from upper-middle-income countries). The median level of implementation of safe practices was 63% (Q1:39%–Q3:77%). Facilities in low-income countries (LICs) reported lower median levels of safe practices than middle-income countries (MICs) [LICs: 32% (Q1:24%–Q3:62%), Lower-MICs: 63% (Q1:49%–Q3:70%), Upper-MICs: 85% (Q1:77%–Q3:93%)]. The biggest differences between country categories were observed in the domains related to personnel, preparation processes, and incident management. Conclusion This overview of practices highlighted a large variability and major gaps in the safe handling of chemotherapy drugs in LMICs. Improvement strategies are needed to increase patient and staff safety and limit environmental contamination, especially in LICs. Safe handling programs should be part of continuing efforts to improve access to quality cancer drugs and should be integrated into national cancer control programs.

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Knowledge and associated factors towards cytotoxic drug handling among University of Gondar Comprehensive Specialized Hospital health professionals, institutional-based cross-sectional study

Cited by 11 publications

References 28 publications

Nurse’s knowledge toward oncology patients during chemotherapy management

Nurse’s knowledge toward oncology patients during chemotherapy management

Development and Proof of Concept of an Audit Toolkit for the Safe Handling of Cytotoxic Drugs in Low- and Middle-Income Countries

The safe handling of chemotherapy drugs in low- and middle-income countries: An overview of practices

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