Introduction. HIV infects more than 2.6 million people/year, reaching 38.0 million by 2019. WHO recognized the disease as a major threat to humanity. Objective. To assess the level of knowledge of HIV-AIDS and associated factors in students during popular events, Évora-Portugal. Methods. Quantitative cross-sectional study, convenience sample, 313 students who visited the institutional pavilion, South Portugal. Sociodemographic data were collected, the HIV Knowledge