Knotted single-stranded DNA rings: A novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli ω protein

Liu, Leroy F.; Depew, Richard E.; Wang, James C.

doi:10.1016/0022-2836(76)90095-4

Cited by 177 publications

(58 citation statements)

References 11 publications

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“…Although the details of the strand passage mechanism are not well understood, the specificity of the strand passage is not limited to homologous DNA. Bacterial topoisomerase I can also catalyze the knotting and unknotting of covalently closed single-stranded DNA (50) or the formation of intertwined duplex rings from rings of complementary sequences (45). Additionally, the enzyme can separate or form catenanes of duplex DNA, if one of the rings contains a single-strand break (95).…”

Section: Introductionmentioning

confidence: 99%

Biochemical characteristics and physiological significance of major DNA topoisomerases

Sutcliffe

Gootz

Barrett

1989

Antimicrob Agents Chemother

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Section: Introductionmentioning

confidence: 99%

Biochemical characteristics and physiological significance of major DNA topoisomerases

Sutcliffe

Gootz

Barrett

1989

Antimicrob Agents Chemother

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“…Knotting and linking are not limited to ropes 4 and are observed even at a molecular level in DNA 5,6 , polymers 7,8 and single molecules 9 . However, the intricacy of knots in physical systems extends beyond basic mathematical notions of knot theory if the knot is a part of a continuum field.…”

mentioning

confidence: 99%

Topological zoo of free-standing knots in confined chiral nematic fluids

2014

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Knotted fields are an emerging research topic relevant to different areas of physics where topology plays a crucial role. Recent realization of knotted nematic disclinations stabilized by colloidal particles raised a challenge of free-standing knots. Here we demonstrate the creation of free-standing knotted and linked disclination loops in the cholesteric ordering fields, which are confined to spherical droplets with homeotropic surface anchoring. Our approach, using free energy minimization and topological theory, leads to the stabilization of knots via the interplay of the geometric frustration and intrinsic chirality. Selected configurations of the lowest complexity are characterized by knot or link types, disclination lengths and self-linking numbers. When cholesteric pitch becomes short on the confinement scale, the knotted structures change to practically unperturbed cholesteric structures with disclinations expelled close to the surface. The drops with knots could be controlled by optical beams and may be used for photonic elements.

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“…Beispiele fürKnoten in zirkulärer DNAwurden erstmals 1976 [132] beschrieben, ungefähr eine Dekade nach Entdeckung der ersten natürlichen DNA-Verschlingungen. [133,134] Die Topologie der DNAw urde durch Elektronenmikroskopie visualisiert.…”

Section: Knoten In Dnaunclassified

Molekulare Knoten

Fielden¹,

Leigh²,

Woltering³

2017

Angewandte Chemie

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Der erste synthetische Kleeblattknoten wurde in den späten 1980er Jahren hergestellt. Kompliziertere Knotentopologien wurden jedoch erst in den letzten Jahren in molekularer Form erhalten. Die Verknotung molekularer Stränge erzeugt sterische Einschränkungen und kann so wichtige physikalische und chemische Eigenschaften verleihen, unter anderem Chiralität, starkes und selektives Binden von Ionen und katalytische Aktivität. Da die Anzahl und Komplexität molekularer Knoten steigt, wird es für Chemiker immer wichtiger, die Knotennomenklatur anderer Disziplinen zu verwenden. Hier geben wir einen Überblick über die Synthesestrategien für molekulare Knoten und beschreiben die Grundlagen der Knoten‐, Zopf‐ und Tangle‐Theorie in einem für Chemiker und molekulare Strukturen angemessenen Umfang.

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Knotted single-stranded DNA rings: A novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli ω protein

Cited by 177 publications

References 11 publications

Biochemical characteristics and physiological significance of major DNA topoisomerases

Biochemical characteristics and physiological significance of major DNA topoisomerases

Topological zoo of free-standing knots in confined chiral nematic fluids

Molekulare Knoten

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