Knots at Sea

Chiral Separations in Capillary Electrophoresis

“…An intercompany crossvalidation project on the chiral analysis of clenbuterol using 30 mM hydroxypropyl-β-cyclodextrin in 50 mM disodium tetraborate adjusted by H 3 PO 4 to pH 2.2 271 is the first published evidence of this kind. Validation of capillary electrophoretic methods for the testing of the enantiomeric purity of fluparoxan 272 and ropivacaine, 273 the development and validation of the combined potency assay and the enantiomeric purity method for a new chiral pharmaceutical compound, 274 as well as the validation of the enantiomeric separation of ephedrine using MEKC 275 belong to this class of communications. A review on the quantitative applications of chiral capillary electrophoresis which gives indications of the performance of these methods and deals with aspects of their routine use has been published.…”