Suture materials are probably the most common biomedical materials and are used to repair virtually all known body tissues. The primary role of sutures remains that of wound closure; principally the fixing of tissues in opposition in order to facilitate healing. However, the continual evolution of materials has seen the applications of sutures widen with the development of new surgical techniques necessitating a concurrent development of suturing technologies. In this chapter, we provide a brief history of sutures and examine the role of biomedical engineering in the testing and development of suturing materials and techniques, including mechanical property testing under various conditions, knot holding capacities, suturing pattern optimization, suture fixation, and anchoring techniques. The
in vivo
response of the human body to various sutures may have an important effect on the material or mechanical properties of the suture/tissue complex, including the viscoelasticity, the stress relaxation, and the strain rate. In this context, we consider the body's response to suture materials according to the inflammatory response, the histological characteristics, and the differences between absorbable and nonabsorbable suture materials. Further, we explore the emerging types of angiogenic and thrombogenic sutures in relation to the biomedical engineering practices that are being used to develop the great potential of these devices. Finally, we consider the continuing development of biomedically engineered sutures with associated advances in clinical effectiveness.