Knot Formation on DNA Pushed Inside Chiral Nanochannels
Renáta Rusková,
Dušan Račko
Abstract:We performed coarse-grained molecular dynamics simulations of DNA polymers pushed inside infinite open chiral and achiral channels. We investigated the behavior of the polymer metrics in terms of span, monomer distributions and changes of topological state of the polymer in the channels. We also compared the regime of pushing a polymer inside the infinite channel to the case of polymer compression in finite channels of knot factories investigated in earlier works. We observed that the compression in the open c… Show more
“…Interestingly, the results highlighted that the speed at which the suspension becomes well distributed is almost independent of applying heat both before and during the process. Rusková et al [ 3 ] performed coarse-grained molecular dynamics simulations of DNA polymers pushed inside infinite open chiral and achiral channels. They investigated the behavior of the polymer metrics in terms of span, monomer distributions, and changes in the topological state of the polymer in the channels.…”
“…Interestingly, the results highlighted that the speed at which the suspension becomes well distributed is almost independent of applying heat both before and during the process. Rusková et al [ 3 ] performed coarse-grained molecular dynamics simulations of DNA polymers pushed inside infinite open chiral and achiral channels. They investigated the behavior of the polymer metrics in terms of span, monomer distributions, and changes in the topological state of the polymer in the channels.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.