We consider manifold-knot pairs
$(Y,K)$
, where Y is a homology 3-sphere that bounds a homology 4-ball. We show that the minimum genus of a PL surface
$\Sigma $
in a homology ball X, such that
$\partial (X, \Sigma ) = (Y, K)$
can be arbitrarily large. Equivalently, the minimum genus of a surface cobordism in a homology cobordism from
$(Y, K)$
to any knot in
$S^3$
can be arbitrarily large. The proof relies on Heegaard Floer homology.