Knorr pyrazole synthesis

Li, Jie Jack

doi:10.1007/978-3-319-03979-4_148

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 In addition, 3,5disubstituted pyrazoles showed potential for nanomedicine application against malignant gliomas. 4 Several classical approaches to synthesize pyrazoles and pyridines, including the Knorr pyrazole synthesis, 5 Boger pyridine synthesis, 6 Chichibabin pyridine synthesis, 7 Kroḧnke pyridine synthesis, 8 and Hantzsch pyridine synthesis, 9 have been well documented in the literature. In addition, the 1,3dipolar cycloaddition of diazo compounds with alkene and alkyne is well established.…”

Section: ■ Introductionmentioning

confidence: 99%

Sc(OTf)₃-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

2022

View full text Add to dashboard Cite

show abstract

Section: ■ Introductionmentioning

confidence: 99%

Sc(OTf)₃-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

2022

View full text Add to dashboard Cite

show abstract

An Insight into Pyrazole-containing Compounds: Synthesis and Pharmacological Activities

Kumar

Bansal

Goyal

2022

AIA

View full text Add to dashboard Cite

Background: Heterocyclic scaffolds have gained exceptional devotion in the recent years due to their marked utility in bio-organic field. Among these, pyrazole remains a privileged scaffold as broad array of medicinally active agents encompasses this heterocycle as a core nucleus. Pyrazole is a five-membered, aromatic ring containing two nitrogen atoms at adjacent positions are readily able to show interactions with numerous receptor (s), enzymes located on the target cells in biological system. Pyrazole-containing compounds are acknowledged with anticyclooxygenases (anti-inflammatory), carbonic anhydrase inhibitor, α-glycosidase inhibitor, and cholinesterase enzymes inhibitor and anti-DNA gyrases activities. Noticeably, rimonabant, phenylbutazone, fipronil, difenamizole, celecoxib, antipyrine, fezolamide and betazole are few representatives of pyrazole containing drugs. Objectives: The manuscript aims to review the detailed synthetic approaches applied for the synthesis of pyrazole derivatives. In particular, we examine recent scientific finding on antimicrobial, anti-tubercular, antiviral, anticancer and anti-inflammatory perspectives of pyrazole containing analogues. Methods: Pyrazole analogues have been widely explored by scientific community as large number of papers has been published in this regard. Numerous pyrazole-containing analogues have been designed, synthesized, and screened for their in vitro and in vivo bio-efficacy and many of them endowed with commendable pharmacological activities. Pyrazole analogues with superior applications as antiviral, anticancer, and anti-inflammatory efficacy have also been well documented in patents granted to this heterocyclic nucleus. Results: This review outlines the recent advances in medicinal chemistry of pyrazole analogues with a special emphasize of structure-activity relationships to afford ideas for the rational drug-design and discovery and their impact on desired pharmacological applications. Conclusion: The information provided in this manuscript may help the medicinal chemists to generate robust pyrazole analogues with high efficacy.

show abstract

Knorr pyrazole synthesis

Cited by 2 publications

References 8 publications

Sc(OTf)₃-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

Sc(OTf)₃-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

An Insight into Pyrazole-containing Compounds: Synthesis and Pharmacological Activities

Contact Info

Product

Resources

About

Knorr pyrazole synthesis

Cited by 2 publications

References 8 publications

Sc(OTf)3-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

Sc(OTf)3-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

An Insight into Pyrazole-containing Compounds: Synthesis and Pharmacological Activities

Contact Info

Product

Resources

About

Sc(OTf)₃-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides

Sc(OTf)₃-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides