Knorpelknochentransplantation versus autogene Chondrocytentransplantation Eine prospektive vergleichende klinische Studie

Abstract

At the time we prefer OCT instead of ACT given the correct indication.

Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells

“…Substantial losses of cartilage tissue require sophisticated therapeutic strategies, because most lesions hardly show any endogenous repair response [1,2]. The transplantation of osteochondral cylinders from an unaffected region of the joint or the recently introduced method of autologous chondrocyte implantation [3] have led to promising results in a number of clinical studies [4,5]; however, both methods are limited to relatively small defects, and the isolation of the osteochondral graft or the articular chondrocytes is associated with donor site morbidity and may itself initiate or exacerbate a degenerative process. Therefore, different attempts have been made to identify a cell population in the adult organism which would be able to undergo chondrogenic differentiation and could be obtained by minimally invasive procedures in large quantities.…”

State of the art and future perspectives of articular cartilage regeneration: a focus on adipose-derived stem cells and platelet-derived products

“…With a follow-up period of 2-10 years, results of clinical studies revealed wellintegrated repair tissue in 90% of treated patients (Peterson et al, 2003). One of the drawbacks of this method is the symptomatic hypertrophy of the periosteal flap in 5-25% of cases (Horas et al, 2000). As an alternative to periosteal flaps, collagen membranes, e.g.…”

Endochondral Bone Formation as Blueprint for Regenerative Medicine

“…Mosaicplasty or OATS involves harvesting one or more osteochondral plugs from a relatively less weight-bearing region of the joint and subsequent implantation of these plugs into an articular defect. Possible donor site morbidity is bypassed if osteochondral allografts are used (Gross, McKee et al 1983;Garrett 1986;Czitrom, Keating et al 1990;Convery, Meyers et al 1991;Garrett 1994;Ghazavi, Pritzker et al 1997;Garrett 1998;Horas, Schnettler et al 2000;Gross, Aubin et al 2002).…”