Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice
Ying Xia,
Emma Andersson,
Mara Caputo
et al.
Abstract:Objective
Non-alcoholic fatty liver disease (NAFLD), the primary hepatic consequence of obesity, is affecting about 25% of the global adult population. The aim of this study was to examine the in vivo role of STE20-type protein kinase TAOK3, which has been previously reported to regulate hepatocellular lipotoxicity in vitro, in the development of NAFLD and systemic insulin resistance in the context of obesity.
Methods
Taok3 knockout mice and wild-t… Show more
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