2008
DOI: 10.1186/1744-9081-4-36
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Knockout mice reveal a role for protein tyrosine phosphatase H1 in cognition

Abstract: BackgroundThe present study has investigated the protein tyrosine phosphatase H1 (PTPH1) expression pattern in mouse brain and its impact on CNS functions.MethodsWe have previously described a PTPH1-KO mouse, generated by replacing the PTP catalytic and the PDZ domain with a LacZ neomycin cassette. PTPH1 expression pattern was evaluated by LacZ staining in the brain and PTPH1-KO and WT mice (n = 10 per gender per genotype) were also behaviorally tested for CNS functions.ResultsIn CNS, PTPH1 is expressed during… Show more

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Cited by 8 publications
(1 citation statement)
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“…Consistent with a neural role, PTPN4-deficient mice were shown to have impaired cerebellar function, including defective motor learning [33] . In a recent report, PTPN3-deficient mice were also shown to have impaired memory function and motor learning, albeit that significant differences compared to controls were detected only in females [34] . Furthermore, in Drosophila , loss of expression of PTPMEG (the single homologue of PTPN3 and PTPN4 in this species) results in defective axon growth associated with impaired development of mushroom bodies [35] .…”
Section: Discussionmentioning
confidence: 91%
“…Consistent with a neural role, PTPN4-deficient mice were shown to have impaired cerebellar function, including defective motor learning [33] . In a recent report, PTPN3-deficient mice were also shown to have impaired memory function and motor learning, albeit that significant differences compared to controls were detected only in females [34] . Furthermore, in Drosophila , loss of expression of PTPMEG (the single homologue of PTPN3 and PTPN4 in this species) results in defective axon growth associated with impaired development of mushroom bodies [35] .…”
Section: Discussionmentioning
confidence: 91%