Knockdown of TRIM44 Inhibits the Proliferation and Invasion in Prostate Cancer Cells

Tan, Yuying; Yao, Hanxin; Hu, Jinghai; Liu, Lingyun

doi:10.3727/096504017x14854310794561

Cited by 33 publications

(41 citation statements)

References 20 publications

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“…Kawabata et al demonstrated that TRIM44 knockdown attenuated the tumor necrosis factor-α-dependent phosphorylation of the p65 subunit of nuclear factor (NF)-κB and inhibitor of NF-κBα in breast cancer cells (11). Another study inferred that the knockdown of TRIM44 inhibited the proliferation and invasion of prostate cancer cells through inactivation of the phosphoinositide 3-kinase/Akt signaling pathway (3). A study in China found that TRIM44 may promote proliferation and metastasis in non-small cell lung cancer via the mammalian target of rapamycin signaling pathway (6).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have suggested that TRIM44 may have an oncogenic role in the invasion and metastases of several types of human cancer, including prostate cancer (3), hepatocellular carcinoma (4), gastric carcinoma (5), non-small cell lung cancer (6) and testicular germ cell tumors (7). However, at present, the precise function of TRIM44 and its underlying carcinogenic mechanism in ovarian cancer remain to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

Liu

Yin

et al. 2018

Exp Ther Med

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Tripartite motif-containing 44 (TRIM44) has been demonstrated to be important in tumor metastasis and progression. However, the expression pattern and prognostic value of the expression of TRIM44 in epithelial ovarian cancer (EOC) remain to be fully elucidated. In the present study, the aim was to investigate the expression and clinical role of TRIM44 in EOC. A total of 109 patients, who underwent primary surgery with the goal of maximal tumor resection followed by standard combination chemotherapy with carboplatin and paclitaxel, were analyzed in the present study. The expression level of TRIM44 was determined by western blot analysis and immunohistochemistry in 109 ECO tissues. It was found that the expression of TRIM44 was low in normal tissues and high in EOC tissues. Univariate survival analysis showed that the overexpression of TRIM44 was significantly associated with International Federation of Gynecology and Obstetrics stage and lymph node metastasis (P<0.05). Kaplan-Meier analysis suggested that there was a significant difference in overall survival and disease-free survival rates between patients with a high expression of TRIM44 and patients with a low expression of TRIM44. Patients with a high expression level of TRIM44 exhibited poorer overall survival and disease-free survival rates, compared with patients expressing a low level of TRIM44 (P<0.001). In addition, the results of the multivariate analysis revealed that the predictive value of the expression of TRIM44 was independent of other clinicopathological factors for predicting prognosis. These findings demonstrated that a high expression of TRIM44 was associated with the progression and prognosis of EOC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

Liu

Yin

et al. 2018

Exp Ther Med

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“…Accumulating studies have shown that TRIM family proteins may positively or negatively regulate carcinogenesis depending on the types of TRIM or the origin of cancer . Specifically, TRIM44 has been reported in a number of studies showing oncogenic effect in various cancers . Ong et al have reported that TRIM44 overexpression resulted from genomic amplification in 16.1% of all epithelial cancers.…”

Section: Discussionmentioning

confidence: 99%

“…The oncogenic effects of TRIM44 have been reported in a number of studies in various types of cancers . We have previously shown that TRIM44 is involved in carcinogenesis of testicular germ cell tumor and breast cancer .…”

Section: Introductionmentioning

confidence: 89%

“…[14][15][16] The oncogenic effects of TRIM44 have been reported in a number of studies in various types of cancers. [17][18][19][20][21][22][23][24][25][26] We have previously shown that TRIM44 is involved in carcinogenesis of testicular germ cell tumor and breast cancer. 21,22 Other reports have suggested its involvement with various pathways, including mTOR, 23,24 NFκB 25 and MAPK.…”

Section: Introductionmentioning

confidence: 99%

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TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma

et al. 2020

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TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression and its function in renal cell carcinoma (RCC) are still unknown. Here in this study, we investigated the clinical significance of TRIM44 and its biological function in RCC. TRIM44 overexpression was significantly associated with clinical M stage, histologic type (clear cell) and presence of lymphatic invasion (P = .047, P = .005, and P = .028, respectively). Moreover, TRIM44 overexpression was significantly associated with poor prognosis in terms of cancer‐specific survival (P = .019). Gain‐of‐function and loss‐of‐function studies using TRIM44 and siTRIM44 transfection showed that TRIM44 promotes cell proliferation and cell migration in two RCC cell lines, Caki1 and 769P. To further investigate the role of TRIM44 in RCC, we performed integrated microarray analysis in Caki1 and 769P cells and explored the data in the Oncomine database. Interestingly, FRK was identified as a promising candidate target gene of TRIM44, which was downregulated in RCC compared with normal renal tissues. We found that cell proliferation was inhibited by TRIM44 knockdown and then recovered by siFRK treatment. Taken together, the present study revealed the association between high expression of TRIM44 and poor prognosis in RCC patients and that TRIM44 promotes cell proliferation by regulating FRK.

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Silencing LINC00491 inhibits prostate cancer development through the miR‐384/TRIM44 axis

Zhou

Tang

et al. 2023

J Biochem & Molecular Tox

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Accumulating evidence has demonstrated the key role of long noncoding (lnc) RNAs in tumorigenesis. Prostate cancer (PCa) is a cancer with high mortality that requires further exploration of the underlying molecular mechanisms. In the present study, we aimed to discover novel potential biomarkers for diagnosing PCa and targeting treatment. Overexpression of the lncRNA, LINC00491, was verified in PCa tumor tissues and cell lines using the realtime polymerase chain reaction. Cell proliferation and invasion were then analyzed via the Cell Counting Kit-8, colony formation, and transwell assays in vitro, and tumor growth in vivo. The interaction of miR-384 with LINC00491, as well as TRIM44, was investigated via bioinformatics analyses, subcellular fractionation, luciferase reporter gene assays, radioimmunoprecipitation, pulldown, and western blot analyses. LINC00491 was overexpressed in PCa tissues and cell lines. LINC00491 knockdown resulted in impaired cell proliferation and invasion in vitro and decreased tumor growth in vivo. Moreover, LINC00491 acted as a sponge for miR-384 and its downstream target, TRIM44. Additionally, miR-384 expression was downregulated in PCa tissues and cell lines, and its expression was negatively correlated with LINC00491. A miR-384 inhibitor restored the inhibitory effects of LINC00491 silencing on PCa cell proliferation and invasion. LINC00491 is a tumor promoter in PCa via enhancing TRIM44 expression by sponging miR-384 to facilitate the development of PCa.LINC00491 plays a significant role in PCa and could serve as both a biomarker for early diagnosis and a novel treatment target.

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Knockdown of TRIM44 Inhibits the Proliferation and Invasion in Prostate Cancer Cells

Cited by 33 publications

References 20 publications

Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer

TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma

Silencing LINC00491 inhibits prostate cancer development through the miR‐384/TRIM44 axis

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