Knockdown of Transmembrane Protein 150A (<i>TMEM150A</i>) Results in Increased Production of Multiple Cytokines

Romanet, Jessica; Cupo, Katherine Lynn; Yoder, Jeffrey A.

doi:10.1089/jir.2022.0063

Cited by 1 publication

(2 citation statements)

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“…in LPS-induced cytokine secretion, indicating that TMEM150A could play a crucial role in cell homeostasis [9]. However, its implications within GBM have not been revealed.…”

Section: Plos Onementioning

confidence: 99%

“…Another member of the transmembrane protein family, TMEM150A, plays a role in cell homeostasis by regulating cytokine secretion and transcription. Decreased TMEM150A expression could result in increased lipopolysaccharide (LPS)-induced cytokine secretion [9]. Furthermore, the relationship between ribonucleic acid (RNA) modifications and GBM progression was inseparable [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses

Fan,

Xu,

et al. 2023

PLoS ONE

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Transmembrane proteins have exhibited a significant correlation with glioblastoma multiforme (GBM). The current study elucidates the roles of transmembrane protein 150A (TMEM150A) in GBM. Data on patients with GBM were collected from The Cancer Genome Atlas and Xena databases. The objective was to identify the expression levels of TMEM150A in patients with GBM, and evaluate its diagnostic and prognostic values, accomplished using the receiver operating characteristic and survival analyses. On a cellular level, Cell Counting Kit-8, Wound healing, and Transwell experiments were performed to gauge the impact of TMEM150A on cell growth and migration. The study further investigated the correlation between TMEM150A expression and immune status, along with ribonucleic acid (RNA) modifications in GBM. The findings demonstrated TMEM150A overexpression in the cancerous tissues of patients with GBM, with an area under the curve value of 0.95. TMEM150A overexpression was significantly correlated with poor prognostic indicators. TMEM150A overexpression and isocitrate dehydrogenase (IDH) mutation status were predictive of poor survival time among patients with GBM. In vitro experiments indicated that suppressing TMEM150A expression could inhibit GBM cell proliferation, migration, and invasion. Moreover, TMEM150A overexpression was associated with stromal, immune, and estimate scores, immune cells (such as the T helper (Th) 17 cells, Th2 cells, and regulatory T cells), cell markers, and RNA modifications. Therefore, TMEM150A overexpression might serve as a promising biomarker for predicting poor prognosis in patients with GBM. Inhibiting TMEM150A expression holds the potential for improving the survival time of patients with GBM.

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“…in LPS-induced cytokine secretion, indicating that TMEM150A could play a crucial role in cell homeostasis [9]. However, its implications within GBM have not been revealed.…”

Section: Plos Onementioning

confidence: 99%